Actively Recruiting
Effects of High Altitude on AMPK Activation
Led by University of Colorado, Denver · Updated on 2026-02-13
84
Participants Needed
1
Research Sites
573 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Pregnancy elicits adaptive changes in uteroplacental blood flow, which are altered at high altitude and may contribute to the observed 3-fold increase in intrauterine growth restriction (IUGR) and preeclampsia (PreE). The investigators propose to collect myometrial, cord blood, and placental tissue samples from women at high altitude (Summit County) and low altitude (Denver) in Colorado in order to determine if residence at altitude during pregnancy changes the vasoreactivity of myometrial arteries (MA). If altered MA vasoreactivity is found, further studies may be able to link these changes to the increased rates of PreE and IUGR at altitude and contribute to the understanding of these two disorders.
CONDITIONS
Official Title
Effects of High Altitude on AMPK Activation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women scheduled for cesarean delivery at University of Colorado Hospital (Denver, 1600 m) and St. Anthony's Summit Medical Center (Summit County, 3000 m)
- Cesarean delivery at a prescheduled time without any labor, typically at 39 weeks gestation
You will not qualify if you...
- Women with medical conditions affecting blood vessels, such as diabetes mellitus, gestational diabetes, hypertensive disorders of pregnancy, or current smokers
- Women with multiple gestations
- Women with preterm deliveries
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Colorado Denver Anschutz Medical Campus
Aurora, Colorado, United States, 80045
Actively Recruiting
Research Team
L
Lorna Moore, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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