Study of High-Fiber Diet Effects on Gut Microbiota, Metabolism, and Immune Response in Adults with Solid Tumors

What this Trial Is About

Cancer is a major global health challenge, with over 19 million new cases and nearly 10 million deaths worldwide annually, most being solid tumors such as lung cancer. Late-stage solid tumors have limited treatment options due to metastasis, treatment toxicities, and resistance to current therapies. Dietary fiber is emerging as a promising adjunct because it may improve immune responses and treatment outcomes by positively affecting gut microbiota and metabolism. This study evaluates a high-insoluble-fiber diet more than 21 grams per day in patients with solid tumors to see how it changes gut bacteria, metabolites, and immune system markers. Participants will follow this diet while researchers assess its safety and tolerability over six weeks. The study will also track treatment responses and quality of life up to one year. Participants will be monitored through laboratory tests, nutritional assessments, and immune profiling during the treatment period. Researchers will measure safety, tumor response rates, and duration of response. The study aims to clarify how dietary fiber affects cancer progression and treatment effectiveness, with follow-up lasting up to one year from enrollment.

Effects of High-Fiber Diet on Gut Microbiota, Metabolism, and Immune Microenvironment in Solid Tumor Patients: A Clinical Study