Actively Recruiting
The Effects of Increasing Caloric Intake on Diet-Induced Thermogenesis and 24h Energy Expenditure
Led by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · Updated on 2026-05-12
120
Participants Needed
1
Research Sites
191 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: Diet-induced thermogenesis (DIT) is the amount of energy one s body uses to eat food, absorb the nutrients from the food, and process those nutrients. Researchers would like to understand more about how changing the balances of protein, fat, carbohydrates, and total calories in the diet can affect DIT. Objective: To learn how different diets can change a person s DIT. Eligibility: Healthy people aged 18 to 60 years who have not intentionally lost weight in the past 6 months. Design: Participants will stay in a clinic for about 35 days. They will eat only the food provided. They will receive 8 different diets during the study, including 7 test diets. Participants will undergo multiple tests. They will be screened with blood and urine tests and a test of their heart function. During the first few days: Their waist, thigh, and neck circumference will be measured. They will have a DXA scan: They will lie on a padded table for about 20 minutes while an instrument measures the amount of fat in their body. They will be tested for diabetes. They will answer questionnaires about topics including eating behavior, hunger, and stress. Throughout the study: Their weight will be measured daily. Blood tests will be repeated. They will stay in a metabolic chamber a total of 9 times. They will remain in a closed room for 24 hours while researchers monitor the room temperature and levels of oxygen and carbon dioxide. Participants will collect all their urine for each 24-hour period. ...
CONDITIONS
Official Title
The Effects of Increasing Caloric Intake on Diet-Induced Thermogenesis and 24h Energy Expenditure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female, aged 18-60 years old
- No episodes of intentional weight loss over previous 6 months
You will not qualify if you...
- Current use of tobacco products with moderate or higher dependence (Fagerstrom score > 2)
- Diabetes diagnosis or fasting glucose ≥ 126 mg/dl or HbA1c ≥ 6.5%
- History of type 1 or type 2 diabetes
- Endocrine disorders including Cushing's disease, pituitary disorders, hypo- or hyperthyroidism
- TSH levels <0.1 or ≥ 10 uIU/mL
- Pulmonary disorders limiting protocol adherence
- Cardiovascular diseases including coronary heart disease, heart failure, arrhythmias, peripheral artery disease
- Hypertension diagnosis or treatment or blood pressure >140/90 mmHg
- Liver disease including cirrhosis, active hepatitis B or C, or elevated liver enzymes
- Renal disease with serum creatinine ≥ 1.5 mg/dl or eGFR <60 mL/min/1.73m2
- Central nervous system disease including stroke, dementia, neurodegenerative disorders
- Cancer requiring treatment in past 5 years except certain cured cancers
- Infectious diseases including active tuberculosis, HIV, chronic infections
- Alcohol abuse (AUDIT score ≥ 8)
- Current use of illegal drugs except marijuana
- Female pregnancy, lactation, or peri- or post-menopause
- Weight ≥ 450 lb (DXA scanner limit)
- Inability to read or speak English
- Inability to provide informed consent
- Psychological conditions incompatible with participation
- Use of medications or supplements altering energy metabolism
- Inability to consume ≥95% of provided diets
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
NIDDK, Phoenix
Phoenix, Arizona, United States, 85004
Actively Recruiting
Research Team
O
Office of Participant Recruitment (NIDDK
CONTACT
T
Tomas Cabeza De Baca, Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
10
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here