Actively Recruiting
The Effects of Insomnia Treatment on Overnight Regulation of Emotional Memories and Risk for Mental Disorders
Led by Woolcock Institute of Medical Research · Updated on 2025-11-26
98
Participants Needed
1
Research Sites
229 weeks
Total Duration
On this page
Sponsors
W
Woolcock Institute of Medical Research
Lead Sponsor
M
Macquarie University, Australia
Collaborating Sponsor
AI-Summary
What this Trial Is About
This project aims to elucidate whether CBCTi changes symptom severity or even remission of anxiety disorders as compared with a delayed-start control group. The investigators will use a delayed-start randomized controlled trial in a cohort of individuals with anxiety and insomnia (N=98) to compare the effects of an online therapist-guided cognitive behavioural and circadian therapy for insomnia versus control on overnight emotion regulation and mental health outcomes. The project will involve at-home assessments and in-lab visits. At-home assessment involves recording sleep and circadian rhythm measures with wearables and daily diaries. Participants will be invited to perform two sleep studies and neuroimaging sessions to investigate the effects of CBCTi on neuroimaging and psychophysiological markers of overnight regulation of emotional distress.
CONDITIONS
Official Title
The Effects of Insomnia Treatment on Overnight Regulation of Emotional Memories and Risk for Mental Disorders
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of insomnia disorder (DSM-5-TR) or Insomnia Severity Index (ISI) score of 10 or higher
- Generalized Anxiety Disorder (GAD-7) score of 10 or higher
- All sexes and genders
- Age between 18 and 45 years
- Able to provide informed consent
- Proficient in English
You will not qualify if you...
- Sleep or circadian disorders other than insomnia, including hypersomnolence, periodic limb movement disorder, advanced or delayed sleep phase disorder, or moderate to severe sleep apnea (apnea-hypopnea index 65 15 or oxygen desaturation index 65 10)
- Current or history of neurological disorders such as stroke or brain injury
- Current or history of bipolar disorder, psychosis, or moderate to severe obsessive-compulsive disorder
- Uncontrolled mental health disorders requiring specialist care other than major depression and anxiety disorders
- Use of centrally active agents or medical conditions affecting participation
- Pregnancy, actively trying to conceive, or lactating
- Shift work of at least two shifts per week in the past three months (work between 21:00 and 6:00)
- Travel across more than three time zones in the past 30 days
- Unwillingness to learn about potential incidental findings
- Lack of consent or inability to adhere to study instructions
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Woolcock Institute of Medical Research
Macquarie Park, New South Wales, Australia, 2109
Actively Recruiting
Research Team
R
Rick Wassing, PhD
CONTACT
A
Aurore Perrault, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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