Actively Recruiting
Effects of Intermittent Fasting and Exercise on Inflammation, Metabolism, and the Microbiome in Metabolic Syndrome
Led by University of Erlangen-Nürnberg Medical School · Updated on 2025-03-20
250
Participants Needed
1
Research Sites
143 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this intervention trial is to assess the effects of intermittent fasting, both alone and in combination with high-intensity interval training, on patients with obesity and metabolic syndrome. The main question it aims to answer is: Does intermittent fasting, with or without high-intensity interval training, reduce chronic inflammation in patients with obesity and metabolic syndrome? Participants will follow an intermittent fasting regime for 3 months, with one intervention group additionally participating in high-intensity interval training twice a week. In addition, there are two control groups: one consisting of participants with metabolic syndrome and one consisting of generally healthy individuals. The study includes a 3-month intervention phase followed by a 3-month follow-up phase. During the 6-month study period, all participants will attend 6 in-house study visits and 2 phone visits, during which they will undergo assessments and receive nutritional counseling.
CONDITIONS
Official Title
Effects of Intermittent Fasting and Exercise on Inflammation, Metabolism, and the Microbiome in Metabolic Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Written consent to participate in the study.
- Persons aged 18 years and older.
- Diagnosis of Metabolic Syndrome (MetS) with elevated hsCRP.
You will not qualify if you...
- Pregnant or nursing individuals.
- Cardiovascular diseases or orthopedic restrictions that prevent exercise.
- Use of medication or supplements that significantly affect study outcomes (e.g., anti-inflammatory medications, antibiotics within the last 6 weeks).
- Body weight greater than 200 kg (maximum capacity of training equipment).
- Individuals with mental illnesses that may impair their ability to understand or participate in the study.
AI-Screening
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Trial Site Locations
Total: 1 location
1
Hector-Center for Nutrition, Exercise and Sports, University Hospital Erlangen
Erlangen, Bavaria, Germany, 91054
Actively Recruiting
Research Team
P
Prof. Dr. med. Yurdagül Zopf
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
5
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