Comparison of Ultrasound-Guided Intra-articular and Combined Peri-articular PRP Injections for Treating Chronic Knee Osteoarthritis Effects on Pain, Function, Daily Activities, and Knee Tissue Thickness

What this Trial Is About

Researchers are studying chronic knee osteoarthritis OA, a common joint disease that causes cartilage breakdown, pain, stiffness, and disability. This trial evaluates and compares two platelet-rich plasma PRP injection methods combined intra-articular and peri-articular injections versus intra-articular injections alone. The goal is to understand how these treatments affect pain, physical function, daily activities, and structural changes in knee tissues like the medial collateral ligament MCL and distal femoral cartilage. Participants will be divided into three groups one receiving conservative treatment with exercise and lifestyle changes another receiving conservative treatment plus ultrasound-guided intra-articular PRP injections and a third group receiving conservative treatment plus combined ultrasound-guided intra-articular and peri-articular PRP injections targeting the MCL and pes anserinus areas. PRP injections are given three times at one-week intervals, using a standardized preparation and photo-activation system to enhance growth factor release. Participants will be assessed at the start, one week after treatment completion, and three months after treatment using pain and function scales like the Visual Analog Scale VAS, Western Ontario and McMaster Universities Osteoarthritis Index WOMAC, and quality of life survey SF-36. Ultrasound measurements of MCL and cartilage thickness will also be taken to track structural changes. Patients will follow exercise therapy and lifestyle recommendations, with adherence monitored during follow-ups. The study aims to provide insights into more effective PRP injection approaches for managing knee OA.

The Effects of Intra-articular and Peri-articular Platelet-rich Plasma (PRP) Injections ın Chronic Knee Osteoarthritis