Actively Recruiting

Phase Not Applicable
Age: 40Years - 65Years
All Genders
ID07339137

The Effects of Platelet-rich Plasma (PRP) Injections Administered Into Intra-articular and Periarticular Regions Under Ultrasound Guidance in Chronic Knee Osteoarthritis on Pain, Function, Activities of Daily Living, Medial Collateral Ligament (MCL) and Distal Femoral Cartilage Thickness

Led by Ankara City Hospital Bilkent · Updated on 2026-01-15

42

Participants Needed

1

Research Sites

12 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are studying chronic knee osteoarthritis (OA), a common joint disease that causes cartilage breakdown, pain, stiffness, and disability. This trial evaluates and compares two platelet-rich plasma (PRP) injection methods: combined intra-articular and peri-articular injections versus intra-articular injections alone. The goal is to understand how these treatments affect pain, physical function, daily activities, and structural changes in knee tissues like the medial collateral ligament (MCL) and distal femoral cartilage. Participants will be divided into three groups: one receiving conservative treatment with exercise and lifestyle changes; another receiving conservative treatment plus ultrasound-guided intra-articular PRP injections; and a third group receiving conservative treatment plus combined ultrasound-guided intra-articular and peri-articular PRP injections targeting the MCL and pes anserinus areas. PRP injections are given three times at one-week intervals, using a standardized preparation and photo-activation system to enhance growth factor release. Participants will be assessed at the start, one week after treatment completion, and three months after treatment using pain and function scales like the Visual Analog Scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and quality of life survey (SF-36). Ultrasound measurements of MCL and cartilage thickness will also be taken to track structural changes. Patients will follow exercise therapy and lifestyle recommendations, with adherence monitored during follow-ups. The study aims to provide insights into more effective PRP injection approaches for managing knee OA.

CONDITIONS

Brief Title

The Effects of Intra-articular and Peri-articular Platelet-rich Plasma (PRP) Injections ın Chronic Knee Osteoarthritis

Who Can Participate

Age: 40Years - 65Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age between 40 and 65 years
  • Patients with significant medial knee pain who have not responded to conservative treatment for at least 3 months
  • Diagnosis of knee osteoarthritis as per American College of Rheumatology (ACR) criteria with Kellgren-Lawrence grade 2 or 3
  • Intact cognitive function
  • Willingness to participate and provide signed informed consent
  • Visual Analog Scale (VAS) score of 4 or higher
Not Eligible

You will not qualify if you...

  • History of previous knee trauma or surgery
  • Physical therapy, intra-articular steroid, or hyaluronic acid injections in the knee within the last 3 months
  • Active cancer or oncological diseases
  • Local infection, sepsis, wounds, or scars in the injection area
  • Systemic infections, hepatitis, or immunosuppression
  • Bleeding disorders or irregular INR due to warfarin use
  • Inflammatory arthritis conditions
  • Uncontrolled hypertension, diabetes, heart failure, coronary artery disease, or asthma
  • Suspected or confirmed pregnancy
  • Use of corticosteroids or opioids
  • Anemia
  • Body mass index (BMI) greater than 35
  • Allergy to citrate
  • Use of NSAIDs within the last week that affect platelet function
  • Signs of patellar retinaculum, meniscus, or cruciate ligament injury
  • General health impairment or lack of cooperation
  • Refusal to participate in the study

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Treatment

Duration - 3 weeks

Participants receive their assigned treatment: conservative therapy only, intra-articular PRP injections plus conservative therapy, or combined intra-articular and peri-articular PRP injections plus conservative therapy. PRP injections are given three times at one-week intervals, with post-procedure recommendations including resting the knee and avoiding certain medications and aggressive exercises.

3 injection visits (in-person)

Follow-up

Duration - Approximately 3 months

Participants are evaluated at 1 week and 3 months after treatment completion to assess pain, function, quality of life, and structural changes using clinical scales and ultrasound measurements.

2 follow-up visits (in-person)

Trial Site Locations

Total: 1 location

1

Ankara Bilkent City Hospital, Physical Therapy and Rehabilitation Hospital

Ankara, Çankaya, Turkey (Türkiye), 06800

Actively Recruiting

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Research Team

R

Rıdvan E ÇELİK

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

3

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Published Research Related To This Trial

The temporal effect of platelet-rich plasma on pain and physical function in the treatment of knee osteoarthritis: systematic review and meta-analysis of randomized controlled trials.

Longxiang Shen, Ting Yuan, Shengbao Chen...

https://pubmed.ncbi.nlm.nih.gov/28115016

Intra-articular and extra-articular platelet-rich plasma injections for knee osteoarthritis: A 26-week, single-arm, pilot feasibility study.

Regina Wing Shan Sit, Ricky Wing Keung Wu, Sheung Wai Law...

https://pubmed.ncbi.nlm.nih.gov/31375446

Three Doses of Platelet-Rich Plasma Therapy Are More Effective Than One Dose of Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-analysis.

Xinyu Tao, Angeline Ai Ling Aw, Jun Jie Leeu...

https://pubmed.ncbi.nlm.nih.gov/37236291

Associations of medial collateral ligament and cartilage thickness with clinical outcomes in medial knee osteoarthritis: a cross-sectional study.

Berke Aras, Rıdvan Çelik, Özge Tezen...

https://pubmed.ncbi.nlm.nih.gov/41247668

Femoral Cartilage Thickness in Knee Osteoarthritis Patients and Healthy Adults: An Ultrasound Measurement Comparison.

Rita Vivera Pane, Rahayu Setiyaningsih, Gunawan Widodo...

https://pubmed.ncbi.nlm.nih.gov/36845755