Actively Recruiting
Effects of Intraoperative Targeted Temperature Management on Incidence of Postoperative Delirium and Long-term Survival
Led by Peking University First Hospital · Updated on 2026-03-09
3992
Participants Needed
36
Research Sites
417 weeks
Total Duration
On this page
Sponsors
P
Peking University First Hospital
Lead Sponsor
P
Peking University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Intraoperative hypothermia is common in patients having major surgery and the compliance with intraoperative temperature monitoring and management remains poor. Studies suggest that intraoperative hypothermia is an important risk factor of postoperative delirium, which is associated with worse early and long-term outcomes. Furthermore, perioperative hypothermia increases stress responses and provokes immune suppression, which might promote cancer recurrence and metastasis. In a recent trial, targeted temperature management reduced intraoperative hypothermia and emergence delirium. There was also a trend of reduced postoperative delirium, although not statistically significant. This trial is designed to test the hypothesis that intraoperative targeted temperature management may reduce postoperative delirium and improves progression-free survival in older patients recovering from major cancer surgery.
CONDITIONS
Official Title
Effects of Intraoperative Targeted Temperature Management on Incidence of Postoperative Delirium and Long-term Survival
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 65 years or older
- Planned potentially curative initial cancer surgery lasting 2 hours or longer under general anesthesia
You will not qualify if you...
- Preoperative fever with tympanic temperature 386C or higher
- Known or suspected preoperative infection
- History of schizophrenia, epilepsy, Parkinson disease, myasthenia gravis, or delirium
- Unable to communicate due to severe dementia, language barrier, or coma
- Critically ill conditions including left ventricular ejection fraction less than 30%, Child-Pugh grade C, need for renal replacement therapy, ASA physical status over IV, or expected survival under 24 hours
- Scheduled surgery for breast cancer, intracranial tumors, or rare cancers
- Planned therapeutic hypothermia
- Body mass index over 30 kg/m2
- Prior participation in this study
- Any other conditions deemed unsuitable for participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 36 locations
1
The People's Hospital of Chizhou
Chizhou, Anhui, China, 247099
Not Yet Recruiting
2
The Second Affiliated Hospital of Anhui Medical University
Hefei, Anhui, China, 230601
Actively Recruiting
3
The First Affiliated Hospital of Anhui Medical University
Hefei, Anhui, China, 610042
Actively Recruiting
4
Maanshan People's Hospital
Ma’anshan, Anhui, China
Actively Recruiting
5
Dongzhimen Hospital Beijing University of Chinese Medicine
Beijing, Beijing Municipality, China, 100007
Not Yet Recruiting
6
Peking University First Hospital
Beijing, Beijing Municipality, China, 100034
Actively Recruiting
7
Guang'anmen Hospital China Academy of Chinese Medical Sciences
Beijing, Beijing Municipality, China, 100055
Actively Recruiting
8
Xiyuan Hospital of China Academy of Chinese Medical Sciences
Beijing, Beijing Municipality, China, 100091
Actively Recruiting
9
Peking Union Medical College Hospital
Beijing, Beijing Municipality, China, 100730
Actively Recruiting
10
Aerospace Medical Center
Beijing, Beijing Municipality, China
Actively Recruiting
11
Beijing Chao-Yang Hospital, Capital Medical University
Beijing, Beijing Municipality, China
Not Yet Recruiting
12
Beijing Chuiyangliu Hospital
Beijing, Beijing Municipality, China
Not Yet Recruiting
13
Beijing Coal Group General Hospital
Beijing, Beijing Municipality, China
Not Yet Recruiting
14
Beijing Electric Power Hospital
Beijing, Beijing Municipality, China
Actively Recruiting
15
Peking University International Hospital
Beijing, Beijing Municipality, China
Not Yet Recruiting
16
The First Hospital of Tsinghua University
Beijing, Beijing Municipality, China
Not Yet Recruiting
17
The First Affiliated Hospital of Chongqing Medical University
Chongqing, Chongqing Municipality, China
Actively Recruiting
18
Peking University Shenzhen Hospital
Shenzhen, Guangdong, China, 518034
Actively Recruiting
19
The Fourth Hospital of Hebei Medical University (Hebei Tumor Hospital)
Shijiazhuang, Hebei, China, 050011
Not Yet Recruiting
20
First Affiliated Hospital of Harbin Medical University
Harbin, Heilongjiang, China, 163711
Actively Recruiting
21
The First Affiliated Hospital Of Zhengzhou University
Zhengzhou, Henan, China, 450052
Actively Recruiting
22
Henan Provincial People's Hospital
Zhengzhou, Henan, China, 463599
Not Yet Recruiting
23
Jingzhou Central Hospital
Jingzhou, Hubei, China
Not Yet Recruiting
24
Jiangyin People's Hospital
Jiangyin, Jiangsu, China, 214400
Actively Recruiting
25
The First Affiliated Hospital of Kangda College of Nanjing Medical University ( Lianyungang First People's Hospital)
Lianyungang, Jiangsu, China
Not Yet Recruiting
26
Jiangsu Province Hospital
Nanjing, Jiangsu, China, 210029
Actively Recruiting
27
The Second Affiliated Hospital of Soochow University
Suzhou, Jiangsu, China
Not Yet Recruiting
28
The People's Hospital of Wuxi
Wuxi, Jiangsu, China, 214023
Not Yet Recruiting
29
Xijing Hospital, Fourth Military Medical University
Xi'an, Shaanxi, China, 710032
Actively Recruiting
30
The First Affiliated Hospital Of Shandong First Medical University
Jinan, Shandong, China, 250013
Not Yet Recruiting
31
The People's Hospital of Liaocheng
Liaocheng, Shandong, China, 252000
Actively Recruiting
32
Chengdu Seventh People's Hospital
Chengdu, Sichuan, China, 610041
Actively Recruiting
33
Sichuan Provincial People's Hospital
Chengdu, Sichuan, China, 610072
Actively Recruiting
34
The First Affiliated Hospital of Chengdu Medical College
Chengdu, Sichuan, China, 610500
Actively Recruiting
35
The Second People's Hospital of Yibin (affiliated with West China Hospital of Sichuan University)
Chengdu, Sichuan, China
Not Yet Recruiting
36
Deyang People's Hospital
Deyang, Sichuan, China
Actively Recruiting
Research Team
D
Dong-Xin Wang, MD, PhD
CONTACT
X
Xin-quan Liang, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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