Microdosing: Old Wine in a New Bottle? Current State of Affairs and Future Avenues.
José Afonso, Fábio Yuzo Nakamura, Ivan Baptista...
https://pubmed.ncbi.nlm.nih.gov/36202386Actively Recruiting
Phase Not Applicable
Age: 18Years +
FEMALE
ID07483216
Effects of a Microdoses Isokinetic Exercise Protocol in Women With Fibromyalgia
Led by European University Miguel de Cervantes · Updated on 2026-04-16
36
Participants Needed
1
Research Sites
N/A
Total Duration
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AI-Summary
What this Trial Is About
Fibromyalgia is a chronic condition marked by widespread muscle pain, fatigue, sleep problems, and difficulty functioning, which greatly impacts quality of life. This research aims to study the effects of a low-dose isokinetic exercise program on physical fitness, pain perception, inflammation, and quality of life in women diagnosed with fibromyalgia. The study evaluates how this precise and controlled exercise approach might benefit this group over an eight-week period. Participants will be divided into two groups. One group will take part in an isokinetic exercise program with microdoses, consisting of three sessions per week lasting 20 to 25 minutes each. Each session includes warm-up, knee extension exercises with controlled speed and repetitions, and cool-down stretches. This group will also receive advice on healthy lifestyle habits. The control group will continue their usual treatment and receive general healthy lifestyle recommendations. During the study, participants will undergo evaluations at the start and after eight weeks, including measurements of muscle strength, muscle activity, body composition, pain levels, sleep quality, inflammatory markers, hormone levels, and quality of life questionnaires. Researchers will monitor progress through physical tests and various health assessments. The total study duration for each participant is eight weeks, with key outcomes measured at baseline and the study's completion.
CONDITIONS
Brief Title
Effects of a Isokinetic Exercise in Women With Fibromyalgia
Who Can Participate
Age: 18Years +
FEMALE
Eligibility Criteria
You may qualify if you...
- Women aged 18 years or older diagnosed with fibromyalgia according to current clinical criteria
- Clinical and pharmacological stability during the weeks prior to participation in the study
- Ability to perform supervised exercise and to complete the assessments
- Written informed consent
You will not qualify if you...
- Cardiovascular, neurologic, musculoskeletal or systemic conditions that prevent safe exercise
- Significant change in medication treatment immediately before the study
- Any condition that medically prevents safe participation in the study protocol
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - 8 weeks
Participants assigned to the exercise group perform supervised isokinetic exercise sessions focused on knee extension, with each session including warm-up, main exercise, and cool-down components. The program is conducted over 8 weeks with three sessions per week, each lasting 20-25 minutes. Participants in the control group continue their usual treatment and receive general healthy lifestyle recommendations.
Three sessions per week
Follow-up
Duration - 1 week
Participants complete final assessments evaluating physical and health outcomes after the 8-week intervention period.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
Miguel de Cervantes European University
Valladolid, Valladolid, Spain, 47012
Actively Recruiting
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Research Team
A
Alejandro Santos Lozano, PhD
S
Sergio Maroto Izquierdo, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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Maria Luiza L Albuquerque, Diogo Monteiro, Daniel A Marinho...
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Nuno Couto, Diogo Monteiro, Luís Cid...
https://pubmed.ncbi.nlm.nih.gov/35725780Effectiveness of Exercise on Fatigue and Sleep Quality in Fibromyalgia: A Systematic Review and Meta-analysis of Randomized Trials.
Fernando Estévez-López, Cristina Maestre-Cascales, Deborrah Russell...
https://pubmed.ncbi.nlm.nih.gov/32721388Effectiveness of Therapeutic Exercise in Fibromyalgia Syndrome: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
M Dolores Sosa-Reina, Susana Nunez-Nagy, Tomás Gallego-Izquierdo...
https://pubmed.ncbi.nlm.nih.gov/29291206