Actively Recruiting
Effects of Isotretinoin on Smell
Led by Uşak University · Updated on 2026-05-07
54
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
Sponsors
U
Uşak University
Lead Sponsor
T
The Scientific and Technological Research Council of Turkey
Collaborating Sponsor
AI-Summary
What this Trial Is About
Isotretinoin is a common medicine used to treat moderate to severe acne. It often causes dryness of the skin and the inside of the nose. Because a normal sense of smell depends on a healthy nasal lining, this dryness may affect how well a person can smell. This study will examine whether isotretinoin treatment changes the sense of smell in adults with acne. Before starting isotretinoin, participants will complete a standardized smell test and two short questionnaires about nasal symptoms and quality of life: the Nasal Obstruction Symptom Evaluation (NOSE) scale and the 22-item Sino-Nasal Outcome Test (SNOT-22). After at least 4 weeks of treatment, the same smell test and questionnaires will be repeated. By comparing results before and after treatment, the study will test the hypothesis that isotretinoin has a negative effect on olfactory function and may reduce patients' ability to smell.
CONDITIONS
Official Title
Effects of Isotretinoin on Smell
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with acne and scheduled to start oral isotretinoin as part of routine dermatology care
- Willing to participate and able to give informed consent
- Not currently smoking
- No history of allergic rhinitis, sinusitis, or active upper respiratory infection
- No medical condition known to affect the sense of smell
You will not qualify if you...
- Younger than 18 years or older than 45 years
- Current cigarette smoking
- History of chronic sinonasal disease
- Any condition that would prevent completing the smell test
- Not willing to continue participation or withdrawal of consent at any time
AI-Screening
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Trial Site Locations
Total: 1 location
1
Uşak University Faculty of Medicine
Uşak, Merkez, Turkey (Türkiye), 64300
Actively Recruiting
Research Team
F
Faruk Kadri Bakkal, MD, Asistant Professor
CONTACT
N
Neslihan Demirel Öğüt, MD, Associate Professor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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