Actively Recruiting
Effects of Isotretinoin on Nasal Mucociliary Clearance and Olfactory Function
Led by Uşak University · Updated on 2026-05-07
54
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
U
Uşak University
Lead Sponsor
T
The Scientific and Technological Research Council of Turkey
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating how isotretinoin, a common medicine used to treat moderate to severe acne, affects the sense of smell in adults. The study aims to understand whether the dryness caused by isotretinoin in the nasal lining impacts the ability to smell. This research addresses conflicting results from previous studies by using standardized tests to measure changes in smell function during treatment. Participants will receive oral isotretinoin prescribed by their dermatologist as part of standard acne care. The dosage and length of treatment will be personalized based on each participant's condition and body weight. The study involves two main assessments: a smell test using the Connecticut Chemosensory Clinical Research Center (CCCRC) method and questionnaires about nasal symptoms and quality of life, completed before starting isotretinoin and after at least four weeks of treatment. During the study, participants will complete smell tests and fill out the Nasal Obstruction Symptom Evaluation (NOSE) scale and the 22-item Sino-Nasal Outcome Test (SNOT-22) questionnaires at two time points. Researchers will compare these results to see if isotretinoin changes olfactory function. The study will monitor safety through participant consent and adherence to treatment, with the total participation lasting at least four weeks from treatment start.
CONDITIONS
Brief Title
Effects of Isotretinoin on Smell
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with acne and scheduled to start oral isotretinoin as part of routine dermatology care
- Willing to participate and able to give informed consent
- Not currently smoking
- No history of allergic rhinitis, sinusitis, or active upper respiratory infection
- No medical condition known to affect the sense of smell
You will not qualify if you...
- Younger than 18 years or older than 45 years
- Current cigarette smoking
- History of chronic sinonasal disease
- Any condition that would prevent completing the smell test
- Not willing to continue participation or withdrawal of consent at any time
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - At least 4 weeks
Participants receive oral isotretinoin as prescribed by their dermatologist as part of routine care for acne vulgaris. The dosage and duration follow routine clinical practice.
1 baseline visit and 1 follow-up visit
Trial Site Locations
Total: 1 location
1
Uşak University Faculty of Medicine
Uşak, Merkez, Turkey (Türkiye), 64300
Actively Recruiting
Research Team
F
Faruk Kadri Bakkal, MD, Asistant Professor
N
Neslihan Demirel Öğüt, MD, Associate Professor
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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