Actively Recruiting
Effects of Ketone Esters on Circulating Senescent T Lymphocytes (T Cells) and Inflammation Levels in the Elderly
Led by First Affiliated Hospital of Harbin Medical University · Updated on 2025-07-25
20
Participants Needed
1
Research Sites
51 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Studies have shown that aging can promote a variety of pathological processes, such as myocardial remodeling and cardiac dysfunction caused by ischemia-reperfusion injury and pressure load. Previous studies found that the level of circulating beta-hydroxybutyric acid decreased significantly with age. It has been reported that the ketogenic diet reduces the occurrence of tumors and neurodegenerative diseases in mice, improves motor coordination and endurance, and ultimately extends life span. Current research results have confirmed that ketone bodies have multiple mechanisms to exert beneficial effects on cardiovascular diseases. However, the effect of age-related cardiovascular disease has not been reported. In order to further clarify the role of beta-hydroxybutyric acid in age-related cardiovascular diseases, find new intervention targets for elderly cardiovascular diseases, and develop new effective prevention and treatment measures for elderly cardiovascular diseases. We will further investigate this hypothesis by establishing a clinical cohort of the elderly population.
CONDITIONS
Official Title
Effects of Ketone Esters on Circulating Senescent T Lymphocytes (T Cells) and Inflammation Levels in the Elderly
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 65 and 80 years old
- Participants must be in good health with no history of chronic diseases
You will not qualify if you...
- Use of immunosuppressants or hormone drugs within the past six months
- Significant changes in diet within the past month
- Digestive tract surgery within the past year
- Severe liver dysfunction (alanine aminotransferase level > 3 times upper limit of normal)
- Severe kidney dysfunction (creatinine clearance rate < 30 mL/min)
- History of malignant tumor
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
the First Affiliated Hospital, Harbin Medical University
Harbin, Heilongjiang, China, 150001
Actively Recruiting
Research Team
Y
Yue Li, Doctor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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