Actively Recruiting
Effects of Ketone Supplement and Alcohol on Brain Metabolism
Led by University of Pennsylvania · Updated on 2026-03-25
60
Participants Needed
1
Research Sites
211 weeks
Total Duration
On this page
Sponsors
U
University of Pennsylvania
Lead Sponsor
N
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The research study is being conducted to better understand the effects of ketones and alcohol on brain functioning and brain metabolism. Participants will be asked to undergo three identical MRI visits after three single-dose interventions: (1) drink a ketone supplement drink, (2) drink an alcoholic beverage, (3) no intervention. These interventions will be randomly assigned (meaning everyone receives all 3 interventions, but in different orders).
CONDITIONS
Official Title
Effects of Ketone Supplement and Alcohol on Brain Metabolism
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Able to provide written informed consent and commit to completing study procedures
- Reported consuming 2 or more standard alcoholic drinks on at least one day in the month before consent
- Aged between 21 and 65 years
You will not qualify if you...
- Unable or unwilling to avoid psychoactive medications or alcohol within 24 hours of alcohol lab and MRI procedures
- Current major psychiatric disorder (other than marijuana or nicotine use disorders) interfering with participation
- Taking medications that could interfere with participation or pose hazards (e.g., anticholinergics, antipsychotics, psychotropic drugs)
- Positive urine drug screen for substances other than marijuana on study visits (one repeat allowed)
- Significant physical diseases or abnormalities (e.g., bleeding disorder, pancreatitis, epilepsy, liver/kidney disease, diabetes) or abnormal lab values exceeding limits
- Major gastrointestinal diseases (e.g., GERD, Crohn's disease, IBS, ulcerative colitis, celiac disease, diverticulitis)
- Head trauma with loss of consciousness over 30 minutes
- Pregnant or breastfeeding
- Weight over 250 pounds
- Self-reported claustrophobia
- Contraindications to MRI (e.g., non-removable metal incompatible with MRI)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Center for Studies of Addiction
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
Research Team
T
Timothy Pond, MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
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