Actively Recruiting
Effects of Ketone Supplementation on Alcohol Withdrawal and Brain Metabolism in Alcohol Use Disorder
Led by University of Pennsylvania · Updated on 2025-09-15
30
Participants Needed
1
Research Sites
121 weeks
Total Duration
On this page
Sponsors
U
University of Pennsylvania
Lead Sponsor
N
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn the effects of ketone supplement compared to placebo on alcohol withdrawal symptoms during a 4 day alcohol withdrawal management treatment in adults with moderate to severe alcohol use disorder at the Hospital of the University of Pennsylvania, Cedar Detox Center.
CONDITIONS
Official Title
Effects of Ketone Supplementation on Alcohol Withdrawal and Brain Metabolism in Alcohol Use Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Able to communicate English and provide written informed consent
- Meets current DSM-5 criteria for moderate or severe alcohol use disorder and seeking treatment
- Minimum 3-year history of heavy drinking (self-report)
- Presence of alcohol withdrawal according to DSM-5
You will not qualify if you...
- Current DSM-5 diagnosis of a major psychiatric disorder other than alcohol and nicotine use disorders that would interfere with study procedures
- Major medical problems affecting brain function or ketone supplement use (e.g., epilepsy, diabetes)
- Clinically significant laboratory findings affecting brain function (e.g., HIV+)
- Head trauma with loss of consciousness longer than 30 minutes
- Pregnant or breast-feeding
- Body mass index greater than 35
- Self-reported claustrophobia
- Contraindications to MRI (e.g., metal in the body that cannot be removed)
- Current gastrointestinal, liver, or other significant physical disease interfering with ketone supplement intake
- Significant withdrawal from other substances requiring medication management
- Judged unsuitable for the study by the principal investigator or study physician
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Center for Studies of Addiction
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
Research Team
T
Timothy Pond, MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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