Study of Lentil Protein Hydrolysate Safety and Effects on Blood Pressure, Vascular Function, and Exercise in Healthy Adults Aged 18 to 45

What this Trial Is About

Researchers are evaluating the safety and tolerability of a plant-based supplement called lentil protein hydrolysate LPH in healthy men and women aged 18 to 45. The study also explores how different doses of LPH affect blood pressure control, vascular health, and exercise performance over a 4-week period. This trial aims to understand the impact of LPH on markers of vascular age, fatigue, quality of life, grip strength, and cardiorespiratory fitness. Participants will be randomly assigned to receive one of several doses of lentil protein hydrolysate 500 mg, 1000 mg, or 2000 mg daily or a placebo containing microcrystalline cellulose. The intervention lasts 4 weeks, during which participants will take the assigned supplement daily. The study uses a wearable device to continuously monitor physical activity, cardiac health, sleep, and heart rate variability. Throughout the 4 weeks, participants will undergo regular assessments including monitoring for adverse events, clinic blood pressure measurements, and exercise testing to measure fitness and substrate use. Safety tests such as liver function and electrolyte levels will also be conducted. Additional evaluations include arterial stiffness, endothelial function, fatigue questionnaires, quality of life surveys, grip strength tests, and inflammation markers. The total participation duration is 28 days with close monitoring of safety and tolerability.

Effects of Lentil Protein Hydrolysate on Blood Pressure Control, Vascular Function and Exercise Performance