Actively Recruiting
Effects of Low-dose Esmolol on Myocardial Injury After Non-cardiac Surgery in Elderly Frail Patients
Led by Yongtao Sun · Updated on 2023-03-29
2000
Participants Needed
1
Research Sites
203 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This topic will focus on the following questions: 1. Part one: To clarify the relationship between preoperative frailty and myocardial injury (cTnT ≥0.03) after non-cardiac surgery in elderly patients; To further explore the predictive factors of myocardial injury after non-cardiac surgery （MINS） in elderly frail patients before operation. 2. Part Two: To explore the effect of low-dose esmolol on myocardial injury after non-cardiac surgery in frail elderly patients.
CONDITIONS
Official Title
Effects of Low-dose Esmolol on Myocardial Injury After Non-cardiac Surgery in Elderly Frail Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 65 years or older
- ASA physical status I to III
- Modified frailty index (mFI) of 0.21 or higher
- Scheduled for non-cardiac surgery
You will not qualify if you...
- Refusal to participate
- Expected hospital stay less than 3 days
- Preoperative beta-blocker therapy
- History of myocardial infarction or coronary artery disease
- Preoperative heart rate below 50 beats per minute or arrhythmia
- Significant cardiac insufficiency (pulmonary artery pressure over 18 mm Hg or cardiac index 2.2 L/min/m2 or less)
- Severe valvular heart disease
- Severe lung disease such as asthma or chronic obstructive pulmonary disease
- Perioperative troponin elevation due to non-ischemic causes like sepsis, pulmonary embolism, or arrhythmia
- Participation only once regardless of multiple surgeries
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Qianfoshan Hospital, The First Hospital affiliated of Shandong First Medical University
Jinan, Shandong, China
Actively Recruiting
Research Team
Y
yongtao Sun, PH.D
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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