Effects of Low Tidal Volume and Airway Pressure Release Ventilation on Lung Tissue Mechanics in ARDS Patients Under Mechanical Ventilation: A Prospective Randomized Crossover Study

What this Trial Is About

Researchers are studying how two types of mechanical ventilation, low tidal volume ventilation (LTV) and airway pressure release ventilation (APRV), affect lung tissue mechanics in adults with Acute Respiratory Distress Syndrome (ARDS). The main goal is to determine which ventilation method better improves lung function and patient safety during mechanical ventilation. This prospective randomized crossover study is led by Union Hospital, Tongji Medical College, Huazhong University of Science and Technology. Participants will receive either APRV or LTV during the trial. In the APRV group, mechanical ventilation involves setting a high pressure based on the plateau pressure from LTV, with specific timing to maintain lung recruitment and optimize airflow. The study compares these two ventilation modes to observe their effects on lung tissue mechanics and respiratory function in ARDS patients. During the study, researchers will measure dynamic relative regional lung strain (DRRS), mechanical power, platform pressure, and mean airway pressure over a maximum of 4 hours. Participants will be closely monitored to evaluate how each ventilation method influences lung mechanics. The trial includes adults aged 18 to 80 years who meet specific ARDS criteria and are under invasive mechanical ventilation. Consent from patients or family members is required for participation.

Effects of Low Tidal Volume and Airway Pressure Release Ventilation on Lung Tissue Mechanics in ARDS Patients Under Mechanical Ventilation: A Prospective Randomized Crossover Study