Actively Recruiting
Effects of Low Tidal Volume and Airway Pressure Release Ventilation on Lung Tissue Mechanics in ARDS Patients Under Mechanical Ventilation: A Prospective Randomized Crossover Study
Led by Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Updated on 2025-01-24
15
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn how low tidal volume ventilation (LTV) and airway pressure release ventilation (APRV) affect lung tissue mechanics in adults with ARDS. The main questions it aims to answer are: Does LTV or APRV improve lung tissue mechanics in patients with ARDS under mechanical ventilation? Researchers will compare LTV and APRV to see which ventilation mode works better for improving lung mechanics and patient safety.
CONDITIONS
Official Title
Effects of Low Tidal Volume and Airway Pressure Release Ventilation on Lung Tissue Mechanics in ARDS Patients Under Mechanical Ventilation: A Prospective Randomized Crossover Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Meets the diagnostic criteria of the 2023 Global New Definition of ARDS.
- Age between 18 and 80 years.
- PaO2/FiO2 ratio less than or equal to 200.
- Within 12 hours of starting invasive mechanical ventilation.
- Consent obtained from the patient or family and signed informed consent form.
You will not qualify if you...
- Age less than 18 years or over 80 years.
- Uncorrected shock of any type.
- Chronic obstructive pulmonary disease (COPD), pulmonary embolism, right heart failure, pulmonary hypertension, or severe arrhythmia.
- Contraindications for Electrical Impedance Tomography (EIT), such as extensive chest skin damage, infection, pacemaker implantation, implanted automatic defibrillator, pneumothorax, mediastinal emphysema, or large pleural effusion.
- Pregnant or breastfeeding women.
- Planned extracorporeal membrane oxygenation (ECMO) treatment.
- Current or previous participation in other clinical studies.
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, China
Actively Recruiting
Research Team
X
Xiaojing Zou Professor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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