Lung stress and strain during mechanical ventilation: any safe threshold?
Alessandro Protti, Massimo Cressoni, Alessandro Santini...
https://pubmed.ncbi.nlm.nih.gov/21297069Actively Recruiting
Phase Not Applicable
Age: 18Years - 80Years
All Genders
ID06790875
Effects of Low Tidal Volume and Airway Pressure Release Ventilation on Lung Tissue Mechanics in ARDS Patients Under Mechanical Ventilation A Prospective Randomized Crossover Study
Led by Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Updated on 2025-01-24
15
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating how two different mechanical ventilation methods, low tidal volume ventilation (LTV) and airway pressure release ventilation (APRV), affect lung tissue mechanics in adults with Acute Respiratory Distress Syndrome (ARDS). The study aims to determine which ventilation mode better improves lung function and patient safety during mechanical ventilation. This is a prospective randomized crossover study comparing these two approaches in ARDS patients. Participants will receive APRV, a pressure-controlled ventilation method where high pressure is set based on plateau pressure during LTV, with specific timing for high and low pressures to promote lung recruitment and optimize breathing. The study compares APRV to LTV, assessing their effects on lung tissue mechanics and oxygenation. During the study, researchers will monitor the impact of the two ventilation methods on dynamic relative regional lung strain over a maximum of 4 hours. Participants will be assessed using clinical and respiratory measures to understand lung function changes. Safety and respiratory responses will be closely observed throughout the study period.
CONDITIONS
Official Title
Effects of Low Tidal Volume and Airway Pressure Release Ventilation on Lung Tissue Mechanics in ARDS Patients Under Mechanical Ventilation: A Prospective Randomized Crossover Study
Who Can Participate
Age: 18Years - 80Years
All Genders
Eligibility Criteria
You may qualify if you...
- Meets the diagnostic criteria of the 2023 Global New Definition of ARDS.
- Age between 18 and 80 years.
- PaO2/FiO2 ratio less than or equal to 200.
- Within 12 hours of starting invasive mechanical ventilation.
- Consent obtained from the patient or family and signed informed consent form.
You will not qualify if you...
- Age less than 18 years or over 80 years.
- Uncorrected shock of any type.
- Chronic obstructive pulmonary disease (COPD), pulmonary embolism, right heart failure, pulmonary hypertension, or severe arrhythmia.
- Contraindications for Electrical Impedance Tomography (EIT), such as extensive chest skin damage, infection, pacemaker implantation, implanted automatic defibrillator, pneumothorax, mediastinal emphysema, or large pleural effusion.
- Pregnant or breastfeeding women.
- Planned extracorporeal membrane oxygenation (ECMO) treatment.
- Current or previous participation in other clinical studies.
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1
2
3
Trial Site Locations
Total: 1 location
1
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, China
Actively Recruiting
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Research Team
X
Xiaojing Zou Professor
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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