Actively Recruiting
Effects of Magnesium Sulfate on Oxygenation and Lung Mechanics During One-Lung Ventilation
Led by Marmara University · Updated on 2026-01-08
104
Participants Needed
1
Research Sites
51 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This prospective observational study aims to evaluate the effects of intravenous magnesium sulfate on intraoperative oxygenation and lung mechanics in patients undergoing thoracic surgery with one-lung ventilation. Magnesium sulfate has been reported to have potential bronchodilatory and anti-inflammatory properties, which may improve gas exchange and respiratory mechanics during lung isolation. In this study, patients who receive magnesium sulfate as part of standard anesthetic management will be compared with those who do not receive the drug. Oxygenation parameters, dynamic and static lung mechanics, airway pressures, and ventilation-related indices will be recorded throughout the intraoperative period. The findings of this study may help clarify whether magnesium sulfate provides measurable respiratory benefits during one-lung ventilation.
CONDITIONS
Official Title
Effects of Magnesium Sulfate on Oxygenation and Lung Mechanics During One-Lung Ventilation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 80 years
- Scheduled for elective thoracic surgery performed with video-assisted thoracoscopic surgery (VATS) requiring one-lung ventilation under general anesthesia
- ASA physical status II-III
- Ability to provide informed consent
- Undergoing general anesthesia with double-lumen tube placement
You will not qualify if you...
- Patients undergoing pneumonectomy
- Patients with renal, hepatic, or cardiovascular failure
- Patients with a BMI < 15 kg/m² or > 35 kg/m²
- Patients with a preoperative pulmonary function test showing FEV1 < 1.5 liters
- Patients who are transferred to the intensive care unit intubated in the postoperative period
- Patients with physical or mental conditions that prevent the performance of pulmonary function testing factors
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Marmara University Faculty of Medicine, Basibuyuk Campus
Istanbul, Turkey (Türkiye), 34854
Actively Recruiting
Research Team
İ
İlayda AKARSU KAYA, Anesthesiology Resident, Principal Investigator
CONTACT
M
Meliha ORHON ERGÜN
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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