Actively Recruiting
The Effects of Metabolic & Bariatric Surgery on Lipid Metabolism, Myeloid-Derived Suppressor Cells, and Cancer Cell Biology
Led by Pennington Biomedical Research Center · Updated on 2025-02-17
20
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to determine the relationship between lipid kinetics changes and blood immunosuppressive cells by metabolic surgery in two patient cohorts.
CONDITIONS
Official Title
The Effects of Metabolic & Bariatric Surgery on Lipid Metabolism, Myeloid-Derived Suppressor Cells, and Cancer Cell Biology
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Biological female sex
- Age between 35 and 60 years (including pre- and postmenopausal)
- Self-reported white or black race
- Approximately 50% white and 50% black participants will be enrolled
- Body mass index of 40 kg/m2 or higher
- Diagnosis of hyperlipidemia or receiving treatment for hyperlipidemia at enrollment
- Ability to provide written informed consent
- Willingness to allow collection and storage of biospecimens and data for future use
- Have not started the pre-operative liquid diet before bariatric surgery
You will not qualify if you...
- Diagnosis of type one or type two diabetes
- Use of anti-inflammatory medications such as glucocorticoids or non-steroidal anti-inflammatory drugs within the past 15 days
- Use of medications approved for obesity management (e.g., phentermine-topiramate, orlistat, naltrexone-bupropion, liraglutide, semaglutide)
- History of any type of cancer
- History of chronic inflammatory conditions like tuberculosis, autoimmune disease, or HIV
- Acute or confirmed/suspected COVID-19 infection within the past 60 days
- Currently pregnant, breastfeeding, or planning pregnancy within the next 52 weeks
- Currently participating in another study with competing outcomes
- Any other condition judged by the investigator to affect safety or study compliance
AI-Screening
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Trial Site Locations
Total: 1 location
1
Pennington Biomedical Resarch Center
Baton Rouge, Louisiana, United States, 70808
Actively Recruiting
Research Team
Z
Zubaidah Nor Hanipah, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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