Actively Recruiting
Effects of Microbiological and Immunological Factors on the Lower Urinary Tract
Led by University of Zurich · Updated on 2026-03-27
800
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University of Zurich
Lead Sponsor
K
Kessler Group
Collaborating Sponsor
AI-Summary
What this Trial Is About
Millions of people worldwide experience various urinary problems such as lower urinary tract dysfunction, bladder pain syndrome, urinary tract infections, and bladder cancer. This research aims to study the relationship between the bladder and the microbiome by looking at microbiological and immune factors and how they relate to lower urinary tract health in humans. The study is observational and led by the University of Zurich, focusing on different urinary conditions and healthy controls. Participants are divided into several groups based on their urinary health, including healthy individuals and those with different types of urinary tract infections, bladder pain, overactive bladder symptoms, and bladder cancer. The study involves collecting samples such as urine, vaginal or urethral swabs, rectal swabs, and blood. Participants also complete various questionnaires and keep diaries tracking their bladder and bowel habits over several days. During the study, participants will provide these samples and complete diaries and questionnaires to help researchers analyze clinical data and immune and microbiome markers for different urinary conditions. The main goal is to evaluate these differences over a one-year period. The study includes repeated sample collections and assessments, and participants will be monitored throughout this time to gather comprehensive information about their urinary health.
CONDITIONS
Brief Title
Effects of Microbiological and Immunological Factors on the Lower Urinary Tract
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women and men aged 18 years or older
- Able to give informed consent to participate
- Willing to follow the study protocol throughout the trial
- Willing to undergo repeated single catheterizations
- Specific urinary conditions as defined for each study group: healthy controls; asymptomatic bacteriuria with or without catheter use; acute and recurrent urinary tract infections; chronic pelvic pain; overactive bladder symptoms; non-muscle-invasive bladder cancer
You will not qualify if you...
- Current or recent (last 21 days) antibiotic treatment except for certain UTI groups
- Urinary tract infections caused by treatable conditions needing specific therapy
- Therapies to prevent UTIs in the past 21 days except for certain UTI groups
- Deterioration of upper urinary tract requiring medical intervention
- Immunomodulatory or immunosuppressant therapies (with exceptions)
- Congenital or acquired lower urinary tract malformations (healthy controls only)
- Need for antiviral medication (healthy controls only)
- Severe systemic diseases or active malignancy except bladder cancer
- Unstable medical or psychiatric conditions posing risk
- Drug or alcohol dependence in the past 6 months
- Pregnancy or nursing
- Inability to follow study procedures due to language or cognitive issues
- Participation in other clinical trials within 4 weeks or as per local rules
- Unconsciousness or hypersensitivity to related medicinal products
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 year
Participants undergo bio-sampling and complete various questionnaires and diaries to evaluate clinical, immunological, and biome markers related to lower urinary tract conditions.
Multiple visits for bio-sampling and assessments over 1 year
Trial Site Locations
Total: 1 location
1
Balgrist University Hospital
Zurich, Canton of Zurich, Switzerland, 8008
Actively Recruiting
Research Team
T
Thomas Kessler Kessler
L
Lorenz Leitner, PD Dr. med.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
10
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