Study of Microbiological and Immune Factors Affecting Lower Urinary Tract Health in Adults

What this Trial Is About

Millions of people worldwide experience various urinary problems such as lower urinary tract dysfunction, bladder pain syndrome, urinary tract infections, and bladder cancer. This research aims to study the relationship between the bladder and the microbiome by looking at microbiological and immune factors and how they relate to lower urinary tract health in humans. The study is observational and led by the University of Zurich, focusing on different urinary conditions and healthy controls. Participants are divided into several groups based on their urinary health, including healthy individuals and those with different types of urinary tract infections, bladder pain, overactive bladder symptoms, and bladder cancer. The study involves collecting samples such as urine, vaginal or urethral swabs, rectal swabs, and blood. Participants also complete various questionnaires and keep diaries tracking their bladder and bowel habits over several days. During the study, participants will provide these samples and complete diaries and questionnaires to help researchers analyze clinical data and immune and microbiome markers for different urinary conditions. The main goal is to evaluate these differences over a one-year period. The study includes repeated sample collections and assessments, and participants will be monitored throughout this time to gather comprehensive information about their urinary health.

Effects of Microbiological and Immunological Factors on the Lower Urinary Tract