Actively Recruiting
Effects of Microbiological and Immunological Factors on the Lower Urinary Tract
Led by University of Zurich · Updated on 2026-03-27
800
Participants Needed
1
Research Sites
182 weeks
Total Duration
On this page
Sponsors
U
University of Zurich
Lead Sponsor
K
Kessler Group
Collaborating Sponsor
AI-Summary
What this Trial Is About
Millions of patients of all ages suffer worldwide from diverse urinary pathologies, such as lower urinary tract (LUT) dysfunction, bladder pain syndrome, urinary tract infections (UTIs), or bladder cancer. The research project investigates the interplay between the bladder and the microbiome. The goal is to evaluate the association of microbiological and immunological factors with lower urinary tract health in humans.
CONDITIONS
Official Title
Effects of Microbiological and Immunological Factors on the Lower Urinary Tract
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women and men aged 18 years or older
- Able to give informed consent for participation in the study
- Willing to adhere to the study protocol for the entire trial period
- Willing to undergo repeated in-and-out single catheterization
- Participants assigned to specific study arms based on urinary tract health status, including healthy controls, asymptomatic bacteriuria, acute and recurrent UTIs (catheter and non-catheter associated), chronic pelvic pain, overactive bladder syndrome, and non-muscle-invasive bladder cancer
You will not qualify if you...
- Current antibiotic treatment or antibiotic treatment within the last 21 days (except for certain UTI study arms)
- Urinary tract infections caused by treatable conditions requiring specific therapy
- Current or recent therapies for preventing UTIs within the last 21 days (except for certain UTI study arms)
- Worsening upper urinary tract conditions needing medical intervention
- Immunomodulatory therapies other than routine vaccination
- Congenital or acquired lower urinary tract malformations (healthy control arm only)
- Immunosuppressant or antiviral therapies (healthy control arm only)
- Severe or unstable systemic diseases including lung, liver (except uncomplicated Hepatitis A), gastrointestinal, cardiac, kidney, immunodeficiency, active malignancy (except bladder cancer), or psychiatric disorders
- Drug or alcohol dependence in the last 6 months
- Pregnant or nursing women
- Inability to follow study procedures due to language, psychological, or cognitive issues
- Participation in other clinical trials within 4 weeks or longer if required
- Unconscious patients or those sedated by medication
- History of hypersensitivity to study drugs or similar compounds
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Balgrist University Hospital
Zurich, Canton of Zurich, Switzerland, 8008
Actively Recruiting
Research Team
T
Thomas Kessler Kessler
CONTACT
L
Lorenz Leitner, PD Dr. med.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
10
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