Actively Recruiting
Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure
Led by Vanderbilt University Medical Center · Updated on 2025-10-14
34
Participants Needed
1
Research Sites
534 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to learn more about the effects of midodrine and droxidopa, two medications used for the treatment of orthostatic hypotension (low blood pressure on standing), on the veins of the abdomen of patients with autonomic failure. The study will be conducted at Vanderbilt University Medical Center, and consists of 2 parts: a screening and 2 testing days. The total length of the study will be about 5 days. About 34 participants will be screened for the study.
CONDITIONS
Official Title
Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male and female subjects, age 40-80 years with possible or probable Multiple System Atrophy, Pure Autonomic Failure, or Parkinson disease, as defined by Consensus Criteria.
- Neurogenic orthostatic hypotension defined as a 630-mmHg decrease in systolic blood pressure within 3 minutes of standing associated with impaired autonomic reflexes determined by autonomic testing in the absence of other identifiable causes.
- Subjects able and willing to provide informed consent.
You will not qualify if you...
- Supine hypertension, defined as systolic blood pressure of 65 160 mmHg measured on two separate occasions.
- Pregnancy.
- Systemic illnesses known to produce autonomic neuropathy, including but not limited to diabetes mellitus, amyloidosis, monoclonal gammopathies, and autoimmune neuropathies.
- History of known aortic aneurisms, thoracic, abdominal or pelvic surgery in the past 6 months.
- Symptomatic abdominal or inguinal hernias.
- Severe gastroesophageal reflux.
- Recent fractures or fissures of ribs, thoracic or lumbar spine.
- Medical devices implanted on the abdominal wall or abdomen that would interfere with the abdominal compression.
- Intolerance to any increase in intraabdominal pressure.
- Clinically unstable coronary artery disease or major cardiovascular or neurological event in the past 6 months.
- Other factors which in the investigator's opinion would prevent the subject from completing the protocol including clinically significant abnormalities in clinical, mental or laboratory testing.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Autonomic Dysfunction Center/ Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232
Actively Recruiting
Research Team
B
Bonnie K Black, RN
CONTACT
L
Luis E Okamoto, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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