Actively Recruiting
Effects of Multi-day Interruptions in Sitting on Type 2 Diabetes-relevant Outcomes in Children
Led by University of Southern California · Updated on 2025-06-05
188
Participants Needed
1
Research Sites
234 weeks
Total Duration
On this page
Sponsors
U
University of Southern California
Lead Sponsor
D
Dana-Farber Cancer Institute
Collaborating Sponsor
AI-Summary
What this Trial Is About
The overall objective of this in-lab randomized controlled trial is to test the efficacy of multi-day interruptions in sedentary behavior vs. single bouts of sustained exercise on metabolic, cognitive, affective, and cardiac autonomic nervous system responses in children with overweight and obesity who are at risk for type 2 diabetes. The use of continuous glucose monitoring will provide insight into the daily and cumulative metabolic effects of each condition that have thus far not been studied. In-lab studies demonstrating sustained efficacy of this approach in ameliorating negative effects of sedentary behaviors in children are necessary for the optimization of field-based interventions. Given the lack of success of interventions to prevent obesity-related diseases and increasing rates of type 2 diabetes in children and its related healthcare costs, this study addresses a critical public health need by testing of novel intervention strategies to reduce obesity-related diseases in children with overweight and obesity.
CONDITIONS
Official Title
Effects of Multi-day Interruptions in Sitting on Type 2 Diabetes-relevant Outcomes in Children
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 8-11 years old
- Good general health
- Body mass index (BMI) at or above the 85th percentile for age
You will not qualify if you...
- Significant heart or lung disease causing low oxygen levels or poor blood flow
- Diagnosis of type 2 diabetes or other hormone disorders causing obesity, such as Cushing Syndrome
- Current or past use of antipsychotic medications affecting metabolism
- Treatment for high blood pressure or cholesterol with medications other than diet
- Early puberty or receiving androgen or estrogen therapy
- Use of medications known to affect body weight or composition
AI-Screening
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Trial Site Locations
Total: 1 location
1
Britni Ryan Belcher, PhD, MPH
Los Angeles, California, United States, 90032
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
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