Actively Recruiting
Effects of Nasal Ventilation on Cerebral and Pulmonary Function in Orally Intubated Patients
Led by Assistance Publique - Hôpitaux de Paris · Updated on 2025-12-03
22
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The passage of air through the nasal cavity generates rhythmic oscillations transmitted by the olfactory bulb to the brain, which induces cerebral activation in functional areas and is associated with better cognitive performance compared to oral breathing. Consequently, the abolition of nasal ventilation in patients intubated via the orotracheal route could have deleterious effects on brain activity. Besides the loss of olfaction, the abolition of nasal ventilation could affect brain activity and respiratory control, consequently altering regional pulmonary ventilation. The hypothesis of the study is that nasal ventilation through the passage of humidified nasal airflow in patients intubated via the orotracheal route would be associated with modulation of cerebral electrical activity and tissue oxygenation and a modification of regional pulmonary ventilation.
CONDITIONS
Official Title
Effects of Nasal Ventilation on Cerebral and Pulmonary Function in Orally Intubated Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Diagnosis of hypoxemic acute respiratory failure
- Intubated and on mechanical ventilation for less than 4 days
- PaO2/FiO2 ratio below 200
- Richmond Agitation Sedation Scale (RASS) score less than -4
- Consent obtained from next of kin
- Patient has health insurance
You will not qualify if you...
- Central nervous system diseases such as stroke, multiple sclerosis, or epilepsy
- Psychiatric illnesses documented in medical record, including psychosis or depression
- Hemodynamic instability with noradrenalin dose greater than 2 mg/hour
- Patient receiving AME treatment
- Patients under legal protection such as guardianship or curatorship
- Pregnant or breastfeeding women
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Service de Médecine Intensive Réanimation - Hôpital Pitié -Salpêtrière
Paris, France, 75013
Actively Recruiting
Research Team
M
Martin Dres
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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