Study of Nasal Ventilation Impact on Brain and Lung Function in Adults with Acute Respiratory Failure Who Are Orally Intubated and Sedated

What this Trial Is About

Researchers are investigating how nasal ventilation affects brain and lung function in adults with hypoxemic acute respiratory failure who are sedated and intubated through the mouth. The study focuses on how breathing through the nose with humidified air may influence brain electrical activity, cerebral blood flow, oxygen levels in brain tissue, and lung ventilation compared to no nasal airflow. This research addresses concerns that oral intubation may alter brain activity and respiratory control due to the loss of natural nasal airflow. Participants will undergo six experimental conditions using a nasal ventilation device delivering humidified air at different flow rates 0, 30, and 60 liters per minute and oxygen levels 21% and 100%. Each condition lasts 30 minutes and includes a negative control with no airflow. Measurements include electroencephalogram EEG recordings, cerebral near-infrared spectroscopy NIRS, thoracic electrical impedance tomography, Doppler velocity, and blood gas analysis to assess brain and lung function. During the study, patients will be monitored continuously while sedated and intubated. The research team will record EEG activity to study brain electrical patterns, cerebral perfusion and oxygenation, gas exchange, and lung ventilation distribution under each nasal ventilation condition. The total assessment happens on day 1 at inclusion, with multiple recordings and blood samples taken after every experimental step. This detailed monitoring aims to understand how nasal airflow impacts cerebral and pulmonary function in this patient group.

Effects of Nasal Ventilation on Cerebral and Pulmonary Function in Orally Intubated Patients