Study of Non-Invasive Superficial Craniocervical Lymphatic Drainage NSCLD Effects on Memory and Thinking in Adults with Sleep Deprivation

What this Trial Is About

This research aims to explore the effects of Non-Invasive Superficial Craniocervical Lymphatic Drainage NSCLD on memory and cognitive function in adults experiencing sleep deprivation. Sleep deprivation can impair attention, working memory, and executive function, leading to serious consequences like slowed reaction times and increased errors. The study focuses on a new non-pharmacological approach to address these cognitive impairments by enhancing brain lymphatic flow. Participants will be randomly assigned to receive either NSCLD or a sham-intervention treatment. The NSCLD involves a 30-minute session repeated after a 10-minute break. This device-based intervention is designed to improve cerebrospinal fluid drainage and reduce neuroinflammation. The study includes a baseline assessment, intervention, and a repeat after a two-week washout period. During the study, participants will undergo cognitive and memory tests such as the Digit Span Test and Montreal Cognitive Assessment MoCA at baseline and after treatment. Other evaluations include brain metabolic markers, EEG, heart rate variability, computerized cognitive assessments, and fMRI scans. Researchers will monitor changes in anxiety, stress, and irritability. The total study duration includes initial testing, intervention, and follow-up assessments to measure the effects of NSCLD on cognitive function.

Effects of Non-Invasive Superficial Craniocervical Lymphatic Drainage (NSCLD) on Memory and Cognitive Function in Adults With Sleep Deprivation: A Proof-of-Concept Study