Effects of Non-invasive Ventilation and High-flow Oxygen Therapy on the Lung in Hypoxemic Chest Trauma Patients, a Descriptive Experimental CT Scan Study

What this Trial Is About

Researchers are studying the effects of non-invasive ventilation (NIV) and high flow oxygen therapy (HFO) on the lungs of patients who have suffered chest trauma. The goal is to better understand how these breathing support methods impact lung function shortly after injury, as previous studies are limited and outdated. This study is sponsored by Hospices Civils de Lyon and focuses on patients with hypoxemic chest trauma, using CT scans to measure lung changes. Participants will be randomly assigned to receive either a single 10-minute session of non-invasive ventilation delivered through a naso-buccal mask or a 10-minute session of high flow oxygen therapy delivered via nasal cannula. Both sessions occur directly on the CT scan table. Two chest CT scans are performed: one before the breathing support session as part of usual care and another immediately after the session to assess changes in lung volume and recruitment. During the study, a senior intensivist will monitor participants for comfort and safety. Researchers will evaluate lung volume changes at day 0 using the CT images. The study involves patients admitted to intensive care within five days of chest trauma who require oxygen support and follow-up chest CTs. Participation includes the treatment session and two CT scans, with the primary outcome focused on lung volume improvement after intervention.

Effects of Non-invasive Ventilation Therapies on the Lung in Hypoxemic Chest Trauma Patients