Study on the Effects of Continuing or Stopping Nonsteroidal Anti-Inflammatory Drugs NSAIDs on Recurrence in Patients with Axial Spondyloarthritis After Remission

What this Trial Is About

Researchers are evaluating the effect of nonsteroidal anti-inflammatory drugs NSAIDs on the recurrence of axial spondyloarthritis in patients who have achieved remission. This multicenter, randomized controlled trial aims to compare the recurrence rates between patients who stop NSAIDs therapy and those who continue it after remission. The study focuses on understanding how NSAIDs influence disease activity and flare rates in this condition. Participants are randomly assigned to one of two groups one group will withdraw from NSAIDs therapy following a washout period, while the other will continue their NSAIDs treatment. The study does not use masking, and treatments are monitored over a period of 24 weeks. Various disease activity and functional indices, imaging scores, and blood tests will be assessed to evaluate changes and flare rates between the groups. During the 24-week study period, participants will undergo regular evaluations including Ankylosing Spondylitis Disease Activity Score ASDAS, patient global assessments, back pain measurements, functional and metrology indices, quality of life questionnaires, and blood tests for inflammation markers. Imaging assessments such as MRI and X-rays will also be performed at specified intervals. Researchers will monitor relapse timing, flare rates, and structural changes to better understand NSAIDs therapys role in disease management.

Effects of Nonsteroidal Anti-Inflammatory Drugs in Recurrence of Spondyloarthritis Patients After Remission