Study of Omega-3 Supplements with Gluten-Free Diet for Adults Newly Diagnosed with Celiac Disease to Reduce Inflammation and Improve Gut Health

What this Trial Is About

Researchers are investigating whether omega-3 fatty acid supplements can help reduce inflammation and promote healing in adults recently diagnosed with celiac disease. Celiac disease is an autoimmune condition where eating gluten damages the small intestine, causing symptoms like stomach pain and diarrhea. While a gluten-free diet is the current treatment, some patients continue to experience inflammation, so this study aims to see if adding omega-3 supplements can improve recovery. Participants will be randomly assigned to one of two groups one group will take daily omega-3 supplements containing 2,400 mg of n-3 PUFAs 2,000 mg DHA and 400 mg EPA, while the other group will receive a placebo pill that looks identical. Both groups will follow a supervised gluten-free diet for three months. Throughout this period, clinical symptoms, diet adherence, and safety will be closely monitored, and some participants will have small intestinal biopsies to assess healing. During the study, participants will visit the clinic regularly for checkups, blood tests, and to provide blood and stool samples before and after the intervention. Researchers will analyze inflammation markers in blood cells, study gut bacteria diversity, and assess immune responses and oxidative stress. The main outcome is to measure changes in systemic inflammatory responses, with results helping to understand how omega-3 may influence gut health. Participation is voluntary, with safety monitored throughout, and participants may leave the study at any time without affecting their medical care.

Effects of Omega-3 Fatty Acids on Inflammation and Gut Microbiota in Celiac Disease