Actively Recruiting
The Effects of One-time Intraoperative Methadone During Laparoscopic Hysterectomy in Reducing Opioid Prescription.
Led by Johns Hopkins University · Updated on 2026-01-12
100
Participants Needed
2
Research Sites
90 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Currently, there is a nationwide epidemic of opioid abuse and overdose deaths. One source of excess opioids is overprescribing in the postoperative period. This study aims to find the optimal pain medication plan during and after laparoscopic hysterectomy to eliminate long-term opioid use. Given the increasing opioid abuse and over-prescription post-operatively, an effort should be made to determine whether one time dosing of Methadone, a longer opioid analgesics, intra-operatively is an adequate potential in treating postoperative pain after hysterectomy surgeries. The investigators hypothesize that this could minimize the need for additional post-operative and outpatient opioid prescriptions and decrease the adverse effects that are associated with the consumption, including new opioid abuse. Intervention group will receive methadone intraoperatively while the other group would receive short-acting opioids (standard).
CONDITIONS
Official Title
The Effects of One-time Intraoperative Methadone During Laparoscopic Hysterectomy in Reducing Opioid Prescription.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Individuals with a uterus
- Age 18 years old and above
- Undergoing minimally invasive (laparoscopic or robotic) hysterectomy with ovarian preservation
- Benign indications for hysterectomy
- Agreeing to participate
You will not qualify if you...
- Chronic pain syndromes including fibromyalgia
- Long-term opioid use for more than three months
- Use of agonist-antagonist medications like buprenorphine
- Use of selective serotonin reuptake inhibitors or monoamine oxidase inhibitors
- Conversion to open surgery (laparotomy)
- Allergy or contraindication to methadone, fentanyl, acetaminophen, or oxycodone
- Severe obstructive sleep apnea
- Pregnancy or breastfeeding
AI-Screening
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Trial Site Locations
Total: 2 locations
1
The Johns Hopkins Bayview Medical Center
Baltimore, Maryland, United States, 21224
Actively Recruiting
2
The Johns Hopkins Hospital
Baltimore, Maryland, United States, 21287
Actively Recruiting
Research Team
M
Mostafa Borahay, MD, MBA, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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