Actively Recruiting
The Effects of an Oral Nutritional Intervention on the Small Intestine Microbiome
Led by Société des Produits Nestlé (SPN) · Updated on 2026-04-22
25
Participants Needed
1
Research Sites
13 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a single-center, single-arm study, aiming at enrolling 25 healthy adult participants to evaluate chronic effects of oil. Specifically, we aim to assess the impact on gut microbiome after a one-month intervention with oil.
CONDITIONS
Official Title
The Effects of an Oral Nutritional Intervention on the Small Intestine Microbiome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Males or females aged 18 to 60 years, inclusive, at enrollment.
- Body Mass Index (BMI) of 18.5 but less than 30 kg/m2.
- Healthy based on self-reported medical history.
- No planned changes in diet or medical treatments during the study.
- Willing to collect fecal samples and retrieve sampling capsules from feces.
- Able to understand and sign written informed consent prior to enrollment.
- Willing and able to comply with study requirements for participation.
You will not qualify if you...
- Prior or suspected gastrointestinal disease that may cause fistula formation, strictures, or obstruction risking capsule non-excretion.
- Previous gastrointestinal surgery that may lead to strictures or obstruction risking capsule non-excretion (excluding appendectomy, cholecystectomy, hysterectomy, oophorectomy, hemorrhoid surgery more than 3 months prior).
- History of chronic diarrhea lasting more than 4 weeks.
- History of chronic constipation with fewer than 3 bowel movements per week in the past month.
- Obstructive symptoms in the 3 months before enrollment.
- Diagnosis of organic motility disorders such as gastroparesis or intestinal pseudo-obstruction.
- Diagnosis of any malabsorption disorder.
- History of swallowing disorders with aspiration risk.
- Any current cancer diagnosis or cancer treatment within the past year.
- History of abdominal or pelvic radiation treatment.
- Chronic diseases likely to affect gut motility (e.g., diabetes, biliary tract stones, kidney stones).
- Use of antibacterial or antifungal therapy in the past 3 months.
- Use of medications or supplements affecting gastrointestinal acidity, motility, or microbiota in the past 4 weeks.
- Colon cleanse or bowel preparation in the 2 weeks prior to enrollment.
- Scheduled for MRI during the study period.
- Pregnant or lactating females of childbearing age.
- Alcohol intake exceeding 2 servings per day for males or 1 serving per day for females over a week.
- Current participation in another interventional study.
- Family or hierarchical relationships with research team members.
AI-Screening
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Trial Site Locations
Total: 1 location
1
Clinical Lab
Lausanne, Switzerland, 1000
Actively Recruiting
Research Team
M
Marie-Pierre Pélissou
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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