Actively Recruiting
Effects of Oral Supplement Containing L-Histidine and Antioxidants on Skin Barrier Function and Systemic Inflammation in Rosacea
Led by Integrative Skin Science and Research · Updated on 2024-08-27
24
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Rosacea is a common chronic inflammatory condition that affects the skin and is linked to inflammation and problems with the skin barrier. People with rosacea also often have gut dysfunction. This research aims to understand how taking a supplement might improve the function of the skin and gut barriers and reduce overall inflammation in individuals with rosacea. Participants in this study will take an oral supplement containing L-Histidine and antioxidants. The study will evaluate the effects of this supplement on skin barrier function and systemic inflammation over several weeks. Key measures include transepidermal water loss and blood levels of high sensitivity C-reactive protein at 4 and 8 weeks, along with assessments of gut permeability, fecal calprotectin, and questionnaires on mood and digestion. During the study, participants will undergo various assessments including skin and blood tests, stool sample analysis, and complete mood and digestive health questionnaires at 4 and 8 weeks. These evaluations will help researchers monitor changes in skin and gut barrier function, inflammation levels, and participant well-being. The study includes adults aged 30 to 70 with mild to moderate rosacea and elevated hs-CRP levels. Total participation duration is at least 8 weeks.
CONDITIONS
Brief Title
Effects of Oral Supplement Containing L-Histidine and Antioxidants on the Skin Barrier Function and Systemic Inflammation in Rosacea
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Males and females aged 30 to 70 years
- Mild to moderate rosacea (erythematotelangiectatic or papulopustular types)
- High sensitivity C-reactive protein (hs-CRP) level of 1.0 mg/L or higher
You will not qualify if you...
- Severe rosacea as assessed by the investigator global assessment
- Unwillingness to stop oral supplements or ingredients found in the study product 1 month before enrollment
- Not discontinuing oral L-glutamine or supplements containing L-glutamine 1 month before enrollment
- Unwillingness to stop topical benzoyl peroxide or retinoids 2 weeks before enrollment
- Unwillingness to maintain the same facial regimen throughout the study
- Use of oral antibiotics within 1 month prior to enrollment
- Pregnancy or breastfeeding
- Changes in hormonal contraception or therapies within 3 months prior to enrollment
- Use of oral contraceptive pills or progesterone or estrogen therapies
- Use of isotretinoin within 3 months before enrollment
- Use of finasteride or dutasteride
- Current smoker, smoking within the past year, or over 5 pack-year tobacco smoking history
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 8 weeks
Participants take an oral supplement containing L-Histidine and antioxidants to evaluate its effects on skin barrier function and systemic inflammation in rosacea.
Baseline visit and follow-up visits at 4 weeks and 8 weeks
Trial Site Locations
Total: 1 location
1
Integrative Skin and Research
Sacramento, California, United States, 95815
Actively Recruiting
Research Team
C
Caitlin Egli
M
Milred Min
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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