Study of Oral L-Histidine and Antioxidant Supplement Effects on Skin Barrier and Inflammation in Adults with Rosacea Aged 30 to 70

What this Trial Is About

Rosacea is a common chronic inflammatory condition that affects the skin and is linked to inflammation and problems with the skin barrier. People with rosacea also often have gut dysfunction. This research aims to understand how taking a supplement might improve the function of the skin and gut barriers and reduce overall inflammation in individuals with rosacea. Participants in this study will take an oral supplement containing L-Histidine and antioxidants. The study will evaluate the effects of this supplement on skin barrier function and systemic inflammation over several weeks. Key measures include transepidermal water loss and blood levels of high sensitivity C-reactive protein at 4 and 8 weeks, along with assessments of gut permeability, fecal calprotectin, and questionnaires on mood and digestion. During the study, participants will undergo various assessments including skin and blood tests, stool sample analysis, and complete mood and digestive health questionnaires at 4 and 8 weeks. These evaluations will help researchers monitor changes in skin and gut barrier function, inflammation levels, and participant well-being. The study includes adults aged 30 to 70 with mild to moderate rosacea and elevated hs-CRP levels. Total participation duration is at least 8 weeks.

Effects of Oral Supplement Containing L-Histidine and Antioxidants on the Skin Barrier Function and Systemic Inflammation in Rosacea