Evaluating Oral Tranexamic Acid for Short-Term Recovery After Total Shoulder Replacement Surgery

What this Trial Is About

This trial focuses on patients aged 18 to 79 undergoing primary total shoulder arthroplasty. Researchers are evaluating the short-term clinical outcomes after surgery when patients receive an extended course of oral tranexamic acid. The study is a randomized, triple-blind, phase 3 trial sponsored by the University of Alabama at Birmingham, aiming to assess the effects of this drug compared to a placebo. Participants will be randomly assigned to one of two groups one will receive oral tranexamic acid, and the other will receive an oral placebo. Both treatments are given after surgery to study how they affect recovery over the short term. The study is designed to compare these two oral treatments in patients undergoing shoulder replacement surgery. During the study, participants will be monitored for pain and other clinical outcomes over a two-week period, with pain assessed using a visual analog scale VAS. The study team will track these outcomes to understand the impact of the medication on postoperative recovery. The total participation duration includes this short-term follow-up, with safety and effectiveness evaluated during this time.

Effects of Oral Tranexamic Acid on Short Term Postoperative Outcomes Following Total Shoulder Arthroplasty