Actively Recruiting
Effects of Oxycodone Combined With Pregabalin on Chronic Postsurgical Pain in Spinal Surgery
Led by Beijing Tiantan Hospital · Updated on 2024-08-01
264
Participants Needed
1
Research Sites
62 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Chronic postoperative pain is one of the common perioperative complications, which seriously affects the prognosis of patients. Currently, no specific perioperative pain management strategy has been found to be effective in preventing and treating chronic postoperative pain in patients undergoing spinal surgery. At present, oxycodone has been widely recognized in different surgical populations for the control of acute postoperative pain, but its contribution to chronic postoperative pain remains unknown. Meanwhile, whether pregabalin can reduce the occurrence of chronic postoperative pain remains controversial, and whether the combination of the two drugs can control the occurrence of chronic postoperative pain in a more comprehensive way remains unknown. Therefore, we intend to conduct this randomized-controlled, factorial design study to determine the efficacy and safety of oxycodone combined with pregabalin in the treatment of chronic postoperative pain in patients undergoing spinal surgery.
CONDITIONS
Official Title
Effects of Oxycodone Combined With Pregabalin on Chronic Postsurgical Pain in Spinal Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient undergoing elective spinal surgery
- Ages equal to or more than 18 years old
- ASA physical status classification I-III
- Signed informed consent
You will not qualify if you...
- Allergy to gabapentinoids or oxycodone
- Aphasia or inability to cooperate with assessment scales
- Diagnosed psychiatric disorders
- Severe vital organ insufficiency such as heart failure, renal dysfunction, or liver failure
- Treatment with gabapentin or pregabalin within the last three months
- History of drug abuse
- Body Mass Index over 35 kg/m2
- Pregnant or breastfeeding women
AI-Screening
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Trial Site Locations
Total: 1 location
1
Beijing Tiantan Hospital
Beijing, China, 100070
Actively Recruiting
Research Team
R
Ruquan Han, M.D., Ph D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
FACTORIAL
Primary Purpose
TREATMENT
Number of Arms
4
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