Actively Recruiting
Effects of a Package of Evidence-based Interventions and Implementation Strategies Based on WHO PEN for People Living With HIV and Cardio-metabolic Conditions in Lusaka, Zambia
Led by University of North Carolina, Chapel Hill · Updated on 2025-08-24
5620
Participants Needed
12
Research Sites
130 weeks
Total Duration
On this page
Sponsors
U
University of North Carolina, Chapel Hill
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to evaluate the effects of a multi-level intervention known as "TASKPEN," adapted from the World Health Organization (WHO) Package of Essential Noncommunicable Disease Interventions (WHO-PEN) for the Zambian public health system, on clinical and implementation outcomes for persons living with HIV (PLHIV) with co-morbid cardio-metabolic conditions in Lusaka, Zambia.
CONDITIONS
Official Title
Effects of a Package of Evidence-based Interventions and Implementation Strategies Based on WHO PEN for People Living With HIV and Cardio-metabolic Conditions in Lusaka, Zambia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older living with HIV who seek HIV services at the study sites
- Participants who have not previously taken part in a study survey
- Willing and able to provide written informed consent
- For the nested cohort: evidence of one or more cardio-metabolic conditions or risk factors such as current tobacco use, hypertension, diabetes, prediabetes, or dyslipidemia
- Participants in in-depth interviews must be HIV-positive adults aged 18 or older who have received HIV and/or NCD services at TASKPEN sites
- Focus group participants must be adults aged 18 or older who are non-physician health workers or community health workers involved with TASKPEN
- Key informants must be adults aged 18 or older who are clinic leaders, managers, or policy makers familiar with HIV/NCD issues
- Participants in implementation questionnaires must be HIV-positive adults exposed to TASKPEN or healthcare providers/managers familiar with TASKPEN
- Costing study participants must be HIV-positive adults or healthcare providers/managers familiar with HIV/NCD services at TASKPEN sites
You will not qualify if you...
- Previous participation in a study survey
- People presenting for one-time services only
- Participants planning to transfer HIV care to another site
- Unable or unwilling to provide written informed consent
- Adults without documented HIV infection or without a cardio-metabolic condition or risk factor of interest
- In-depth interview participants without evidence of receiving HIV/NCD services at study sites
- Participants unfamiliar with the TASKPEN intervention
- Any potential participant unwilling or unable to give written informed consent
AI-Screening
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Trial Site Locations
Total: 12 locations
1
Bauleni Health Center
Lusaka, Zambia
Actively Recruiting
2
Chawama 1st Level Hospital
Lusaka, Zambia
Actively Recruiting
3
Chelstone Urban Health Center
Lusaka, Zambia
Actively Recruiting
4
Chipata 1st Level Hospital
Lusaka, Zambia
Actively Recruiting
5
Kabwata Urban Health Center
Lusaka, Zambia
Actively Recruiting
6
Kalingalinga Urban Health Center
Lusaka, Zambia
Actively Recruiting
7
Kamwala Urban Health Center
Lusaka, Zambia
Actively Recruiting
8
Kanyama 1st Level Hospital
Lusaka, Zambia
Actively Recruiting
9
Makeni Urban Health Center
Lusaka, Zambia
Actively Recruiting
10
Mtendere Health Center
Lusaka, Zambia
Actively Recruiting
11
Ng'ombe Urban Health Center
Lusaka, Zambia
Actively Recruiting
12
Railway Urban Health Center
Lusaka, Zambia
Actively Recruiting
Research Team
C
Chilambwe Mwila, MSc
CONTACT
C
Christy Frimpong, MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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