Effects of Partial Sleep Deprivation on Cardiac Output During Cycling Exercise in Healthy Adults

What this Trial Is About

This research aims to understand how partial sleep deprivation affects cardiac output and blood pressure during cycling exercise in young healthy adults, with about half of the participants being female. The study particularly focuses on whether decreases in plasma volume lead to lower cardiac output and blood pressure, and investigates differences between males and females. The trial builds on previous findings that males show reduced systolic blood pressure after partial sleep deprivation while females do not. Participants will take part in three visits. The first visit measures maximal oxygen uptake to assess aerobic fitness and determine exercise intensity zones. The next two visits involve randomized testing after either a normal night of sleep or a night with approximately 40% reduced sleep (partial sleep deprivation). During these visits, participants will perform a 60-minute cycling exercise while researchers measure blood pressure, stroke volume, cardiac output, and plasma volume. Blood samples will be collected through intravenous lines before, during, and after exercise. Participants will keep daily diaries of their sleep and food and beverage intake. Sleep will be monitored for one week before each testing visit using questionnaires and wrist actigraphy. Throughout the study, researchers will assess the cardiac output response to cycling exercise as the primary outcome, along with secondary outcomes including blood pressure and plasma volume responses. The study will last about three weeks, with safety monitoring and adherence to sleep protocols throughout the process.

Effects of Partial Sleep Deprivation on Cardiac Output During Cycling