Feasibility and Safety Evaluation of Lower Respiratory Rate Lung-Protective Ventilation Compared to Conventional Ventilation in Critically Ill Adults

What this Trial Is About

Researchers are evaluating the feasibility and safety of a ventilation strategy called permissive lung-protective ventilation in adult critically ill patients who require invasive mechanical ventilation due to acute hypoxemic respiratory failure. This pilot trial aims to inform the design of a future larger randomized clinical trial by comparing permissive lung-protective ventilation with conventional lung-protective ventilation. The study focuses on how lowering the respiratory rate may reduce ventilation intensity while managing carbon dioxide levels safely. Participants are randomly assigned to one of two groups one group receives permissive lung-protective ventilation where the respiratory rate is gradually reduced based on blood gas analysis and continuous monitoring, allowing mild increases in carbon dioxide levels within safe limits. The other group receives conventional lung-protective ventilation with standard respiratory rates targeting normal carbon dioxide and pH levels. Blood gas analyses are performed frequently to monitor patient status until ventilator weaning or extubation. Throughout the study, participants undergo regular assessments including arterial blood gas tests, continuous end-tidal CO2 monitoring, and data collection on ventilation parameters and outcomes. Researchers measure the feasibility of reducing respiratory rate, adherence to the protocol, safety indicators such as hypercapnia and hypoxemia, and ventilator-associated complications. Data collection continues up to 90 days for follow-up, with the primary evaluation lasting from ventilation start until first extubation, up to 28 days.

Effects of PERMISSive Lung-protective Ventilation on Outcome in Critically Ill Invasively Ventilated Patients