Actively Recruiting

Phase Not Applicable
Age: 9Years - 14Years
All Genders
ID07579585

Effects of Photobiomodulation on Knee Hemarthosis in Patients With Hemophilia

Led by Riphah International University · Updated on 2026-05-12

24

Participants Needed

1

Research Sites

N/A

Total Duration

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AI-Summary

What this Trial Is About

Hemophilia is a genetic bleeding disorder caused by a deficiency in clotting factors VIII or IX, which often leads to spontaneous or injury-related internal bleeding, especially in muscles and joints. Knee hemarthrosis, a common and painful complication in children with hemophilia, results in swelling, pain, and limited joint movement. Researchers are studying the effects of photobiomodulation, a non-invasive light therapy, on knee hemarthrosis in male patients aged 9 to 14 years to see if it can help reduce these symptoms alongside standard treatments. The study uses low-level laser therapy applied directly to the skin over the knee joint at multiple points around the patella. Treatment sessions last 10 minutes and are given three times a week after acute internal bleeding or swelling occurs. Patients receive this photobiomodulation therapy in addition to their usual care. The therapy aims to reduce inflammation and promote tissue repair by stimulating cellular activity. Participants will be evaluated before and after the treatment period. Researchers will measure pain intensity using a Visual Analogue Scale, swelling with a measuring tape, and joint range of motion with a goniometer. These assessments occur on the third day of treatment to track improvements in joint function and hemarthrosis severity. The total study period and detailed monitoring are designed to understand how photobiomodulation may support joint health in children with hemophilia.

CONDITIONS

Brief Title

Effects of Photobiomodulation in Hemophilia Patients.

Who Can Participate

Age: 9Years - 14Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Hemophilia patients with knee hemarthosis
  • Patients aged 9 to 14 years
  • Both male and female patients are included
Not Eligible

You will not qualify if you...

  • Presence of open wounds at or near the treatment site
  • Knee joint subluxation
  • Presence of congenital or acquired skeletal deformities
  • Children diagnosed with cardiopulmonary dysfunctions
  • Children with neurological deficits

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Treatment

Duration - Duration of therapy after an acute bleed or swelling (variable)

Participants receive photobiomodulation therapy using low-level laser applied to the knee joint for 10 minutes, 3 days a week following an acute internal bleed or swelling, alongside standard care.

3 visits per week during treatment

Follow-up

Duration - Assessment on the 3rd day after treatment

Participants’ pain intensity, swelling, and range of motion are assessed post-treatment to evaluate the effectiveness of photobiomodulation.

1 visit (in-person) for outcome assessment

Trial Site Locations

Total: 1 location

1

Sundas Foundation

Sialkot, Punjab Province, Pakistan, 5100

Actively Recruiting

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Research Team

I

Imran Amjad, PhD

M

Muhammad Asif Javed, PhD*

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

TREATMENT

Number of Arms

1

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