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O Laccourreye, H Maisonneuve
https://pubmed.ncbi.nlm.nih.gov/31540851Actively Recruiting
Led by Riphah International University · Updated on 2026-05-12
24
Participants Needed
1
Research Sites
N/A
Total Duration
Hemophilia is a genetic bleeding disorder caused by a deficiency in clotting factors VIII or IX, which often leads to spontaneous or injury-related internal bleeding, especially in muscles and joints. Knee hemarthrosis, a common and painful complication in children with hemophilia, results in swelling, pain, and limited joint movement. Researchers are studying the effects of photobiomodulation, a non-invasive light therapy, on knee hemarthrosis in male patients aged 9 to 14 years to see if it can help reduce these symptoms alongside standard treatments. The study uses low-level laser therapy applied directly to the skin over the knee joint at multiple points around the patella. Treatment sessions last 10 minutes and are given three times a week after acute internal bleeding or swelling occurs. Patients receive this photobiomodulation therapy in addition to their usual care. The therapy aims to reduce inflammation and promote tissue repair by stimulating cellular activity. Participants will be evaluated before and after the treatment period. Researchers will measure pain intensity using a Visual Analogue Scale, swelling with a measuring tape, and joint range of motion with a goniometer. These assessments occur on the third day of treatment to track improvements in joint function and hemarthrosis severity. The total study period and detailed monitoring are designed to understand how photobiomodulation may support joint health in children with hemophilia.
CONDITIONS
Effects of Photobiomodulation in Hemophilia Patients.
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Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Duration of therapy after an acute bleed or swelling (variable)
Participants receive photobiomodulation therapy using low-level laser applied to the knee joint for 10 minutes, 3 days a week following an acute internal bleed or swelling, alongside standard care.
3 visits per week during treatment
Duration - Assessment on the 3rd day after treatment
Participants’ pain intensity, swelling, and range of motion are assessed post-treatment to evaluate the effectiveness of photobiomodulation.
1 visit (in-person) for outcome assessment
Total: 1 location
1
Sundas Foundation
Sialkot, Punjab Province, Pakistan, 5100
Actively Recruiting
I
Imran Amjad, PhD
M
Muhammad Asif Javed, PhD*
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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O Laccourreye, H Maisonneuve
https://pubmed.ncbi.nlm.nih.gov/31540851