Randomized Trial of Plant-Based Diets on Gut and Heart Health in Adults Aged 30 to 70

What this Trial Is About

Researchers are investigating how plant-based diets affect the gut microbiome diversity and cardiometabolic health in healthy adults aged 30 to 70 years. The study aims to determine the impact of different plant foods on the alpha-diversity of gut bacteria and overall metabolic health. This randomized controlled trial compares two diets containing plant foods to evaluate their effects on gastrointestinal and cardiometabolic markers. Participants will follow one of two provided plant-based diets for four weeks, consuming study meals, snacks, and drinks six days per week. They will self-select foods on one day each week following guidance. The study includes two active comparator diet groups, both emphasizing plant foods but differing in composition. Throughout the trial, participants will attend three visits to provide blood, urine, and stool samples. Researchers will assess body composition, blood pressure, and artery ultrasound measurements. Participants will also complete questionnaires about diet, mental health, physical activity, quality of life, and diet adherence. The main outcome measured is the gut microbiota alpha-diversity at week 4, with various other biological and health markers assessed at baseline and week 4. The total study duration includes the four-week diet intervention and multiple assessments.

Effects of Plant Foods on Gastrointestinal and Cardiometabolic Health