Actively Recruiting
The Effects of Platelet Rich Plasma Adjuvant to Type I/III Collagen Ratio, Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 in Pelvic Organ Prolapse Repair
Led by Andalas University · Updated on 2025-09-08
30
Participants Needed
1
Research Sites
48 weeks
Total Duration
On this page
Sponsors
A
Andalas University
Lead Sponsor
D
Dr. M Djamil Hospital, Padang
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to analyze the effect of Platelet Rich Plasma (PRP) Adjuvant To Type I/III Colagen Ratio, MMP-2 and MMP-9 in Pelvic Organ Prolapse Repair. The main questions it aims to answer are: Does the PRP Adjuvant affect type I/III Colagen Ratio, MMP-2 and MMP-9 in Pelvic Organ Prolapse Repair? Researchers will compare patient who undergo prolapse surgery with PRP adjuvant versus patient who undergo prolapse surgery without PRP adjuvant (placeebo) Participants will: Patient will undergo pelvic organ prolapse reconstrucion surgery and punch biopsy and injection of PRP will perform in anterior vaginal mucosa at Pubocervical area. The second biopsy will attempt in 8 weeks post operative. imunohistochemistry examination will be done to compare the type I/III Colagen Ratio, MMP-2 and MMP-9 before and after surgery.
CONDITIONS
Official Title
The Effects of Platelet Rich Plasma Adjuvant to Type I/III Collagen Ratio, Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 in Pelvic Organ Prolapse Repair
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with second-degree or higher pelvic organ prolapse
- Postmenopausal pelvic organ prolapse patients
- Patients with pelvic organ prolapse who will undergo surgery
- Willingness to participate in the study
You will not qualify if you...
- Patients with gynecological malignancies
- Patients with a history of collagen disease
- Patients with blood disorders
AI-Screening
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Trial Site Locations
Total: 1 location
1
Biomedical Science Doctoral Programme Faculty of Medicine Andalas University/ Urogynecology Division Obstetrics and Gynecology Department M Djamil Hospital Padang
Padang, West Sumatera, Indonesia
Actively Recruiting
Research Team
Y
Yulia Margaretta Sari Yulia Margaretta, Sari, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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