Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT07115862

Effects of Pomegranate Juice on Ulcerative Colitis

Led by University of California, Los Angeles · Updated on 2025-12-09

30

Participants Needed

2

Research Sites

104 weeks

Total Duration

On this page

Sponsors

U

University of California, Los Angeles

Lead Sponsor

N

National Institutes of Health (NIH)

Collaborating Sponsor

AI-Summary

What this Trial Is About

The purpose of this study is to determine whether consumption of 237 ml of pomegranate juice daily for 8 weeks will: 1. lower inflammation (in the gut as well as generally in the body) and improve your overall quality of life 2. affect the microbes living in the gut (gut microbiota)

CONDITIONS

Official Title

Effects of Pomegranate Juice on Ulcerative Colitis

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Adults 18 years or older
  • Following a low-polyphenol and fiber diet (less than 3 servings of fruits/vegetables per day)
  • Mild-to-moderate ulcerative colitis at screening (partial Mayo scores between 2 and 5)
  • Evidence of active inflammation with biopsy-confirmed UC (hsCRP >1 mg/L, fecal calprotectin >50 µg/g stool, or abnormal lower endoscopy)
  • Stable dose of 5-aminosalicylates for at least 4 weeks before screening
  • Stable dose of immunosuppressive therapy for at least 8 weeks before baseline
  • Prednisone dose no more than 20 mg/day and budesonide MMX no more than 9 mg/day at baseline
  • Able and willing to provide informed consent
Not Eligible

You will not qualify if you...

  • Non-English speaker
  • Vegetarian or vegan diet
  • Known allergy to pomegranate
  • Chronic diseases other than UC, including diabetes, kidney or liver disease, metabolic syndrome, active cancer, heart attack or stroke history, or gastric bypass
  • Diagnosis of Crohn's disease, indeterminate, severe, or fulminant colitis
  • History of colectomy or colonic dysplasia
  • Presence of ileal pouch or ostomy
  • Active bacterial or viral gastroenteritis based on stool studies
  • Recent hospitalization within 2 weeks for UC needing IV steroids
  • Severe colitis indicated by hemoglobin less than 8.0 g/dl or albumin less than 3.0 g/dl
  • Recent use of systemic antibiotics within 3 months or current use of anti-diarrheal medications
  • Taking supplements that affect metabolism or gut microbiota unless willing to stop during study
  • Use of total parenteral nutrition
  • Use of cyclosporine, tacrolimus, or thalidomide within 2 months before screening
  • Taking exogenous hormones like hormone replacement therapy
  • Recent weight changes over 10% in last 6 months
  • Smoker or living with a smoker
  • Consuming more than 20 grams of alcohol per day
  • Unable or unwilling to follow study protocol or avoid certain foods such as watermelon and lycopene-rich foods
  • Unable to provide informed consent

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 2 locations

1

West Los Angeles VA Medical Center

Los Angeles, California, United States, 90073

Not Yet Recruiting

2

UCLA Center for Human Nutrition

Los Angeles, California, United States, 90095

Actively Recruiting

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Research Team

T

Tatiana Diacova, PhD, MS, RDN

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

CROSSOVER

Primary Purpose

SUPPORTIVE_CARE

Number of Arms

2

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