Actively Recruiting
Effects of Positive End-Expiratory Pressure (PEEP) and Prone Positioning in Healthy Volunteers on Venous Hemodynamics Including the Venous Excess Ultrasound (VExUS) Score
Led by University Hospital, Basel, Switzerland · Updated on 2025-12-09
40
Participants Needed
1
Research Sites
35 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The hemodynamic effects of proning and PEEP may vary depending on pre- existing cardiac function, lung mechanics, and volume status, and the available evidence remains conflicting. The impact on the VExUS score of these manoeuvres is unclear. This study aims to assess the effects of PEEP in supine and prone position on the VExUS score as well as echocardiographic parameters in a cohort of healthy volunteers.
CONDITIONS
Official Title
Effects of Positive End-Expiratory Pressure (PEEP) and Prone Positioning in Healthy Volunteers on Venous Hemodynamics Including the Venous Excess Ultrasound (VExUS) Score
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Voluntary participants aged 18 years or older in good overall health with no significant organ dysfunction
- Signed informed consent form
You will not qualify if you...
- Non-French or non-German speakers
- Unable to provide informed consent
- Body mass index greater than 40 kg/m2
- Self-reported pregnancy
- History of pneumothorax
- Previously participated in the study
AI-Screening
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Trial Site Locations
Total: 1 location
1
University Hospital Basel, Intensive Care Unit
Basel, Switzerland, 4031
Actively Recruiting
Research Team
G
Gregor Loosen, Dr. med.
CONTACT
K
Kaspar Bachmann, PD Dr. med.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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