Actively Recruiting
The Effects of Preemptive Multimodal Analgesic on Endodontic Pain Following Root Canal Therapy.
Led by Chattogram International Dental College · Updated on 2026-02-11
280
Participants Needed
1
Research Sites
64 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
A clinical trial comparing preemptive multimodal analgesics with placebo in the management of immediate and chronic post-endodontic pain. The study utilizes statistical methods such as chi-squared, T-tests, and regression analysis, accounting for multiple outcomes with the Bonferroni adjustment. Duloxetine hydrochloride and pregabalin, both available in Bangladesh, are evaluated as experimental drugs, while placebos are used to assess psychological effects on pain. All participants receive standard interventional treatments, with acetaminophen provided as needed, and ethical considerations are addressed according to international guidelines.
CONDITIONS
Official Title
The Effects of Preemptive Multimodal Analgesic on Endodontic Pain Following Root Canal Therapy.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 18 years or older
- ASA physical status I or II
- Patients with pain originating from teeth and surrounding areas
- Preoperative pain severity is moderate to severe
- Patients able to communicate about their pain
- Patients who give consent to participate in the study
- Patients with other chronic pain conditions
- Patients scheduled for non-surgical endodontic treatment
- Patients scheduled for non-surgical endodontic retreatment
- Patients scheduled for surgical endodontic treatment
You will not qualify if you...
- Patients who do not wish to participate in the study
- Patients with medical conditions contraindicating study drugs
- ASA physical status III, IV, or V
- Patients currently treated with anti-convulsant drugs
- Patients participating in other clinical trials
- Patients with poor motivation or adherence to study protocols
- Pregnant patients
- Patients with severe organ dysfunction
- Patients with hepatitis B or other infectious diseases like HIV
- Patients with uncontrolled comorbidities unsuitable for endodontic treatment
- Patients with severe cognitive impairment
- Patients with history of certain cancers or severe blood disorders
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Professor. Dr. Md. Abu Saeed Ibn Harun
Chittagong, Chattogram, Bangladesh, 4212
Actively Recruiting
Research Team
P
Prof.Dr. Md. Abu Saeed Ibn Harun, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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