Actively Recruiting
The Effects of a Probiotic Food Supplement in Hyperuricaemia
Led by Örebro University, Sweden · Updated on 2026-03-27
99
Participants Needed
1
Research Sites
102 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The overall aim of the project is to determine whether a daily intake of health-promoting bacteria, known as probiotics, with or without a dietary fiber, affects uric acid levels in individuals with elevated levels of uric acid in the blood (hyperuricemia). Additionally, the project will investigate which individuals benefit from this dietary supplement and which do not, based on factors such as gut microbiota composition and function, dietary habits, genetic factors, and inflammatory status. The ultimate goal is to develop a personalized therapy for hyperuricemia. At the beginning of the study, blood samples will be taken to determine uric acid levels and 99 individuals with hyperuricemia will be invited to participate in a 6-week intervention study with daily intake of dietary supplements. To examine the effect of the supplement on various health variables, blood, urine, stool, and breath samples will be collected on several occasions. To better understand the underlying factors of hyperuricemia, questionnaire data and results from biological will be compared between participants with normal versus elevated uric acid levels. Furthermore, different outcome parameters from questionnaires and samples before and after supplement intake will be compared. In addition, various methods for estimating dietary intake will be investigated and compared with each other.
CONDITIONS
Official Title
The Effects of a Probiotic Food Supplement in Hyperuricaemia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed informed consent prior to any study-related procedures
- Age 18-80 years old
- Body mass index (BMI) between 17.5 and 40 kg/m2
- Blood uric acid above 405 bcmol/l (6.8 mg/dl)
- Willing to avoid regular consumption of probiotic supplements or probiotic-containing foods during the study
- Willing to avoid regular use of supplements or medications that affect gut function or inflammation during the study
You will not qualify if you...
- Recent gout episode within the last month
- Diagnosis of type 1 diabetes
- Diagnosed inflammatory bowel disease (IBD)
- Current psychiatric diseases or syndromes
- Current neurodegenerative disease
- Pregnancy or breastfeeding
- History of complicated gastrointestinal surgery
- Partial or full removal of small intestine or colon
- Regular use of urate-lowering drugs other than allopurinol in the last month
- Use of antibiotics or corticosteroids orally or intravenously in the last 4 months
- Regular use of non-steroidal anti-inflammatory drugs (NSAIDs) in the last month except low-dose aspirin
- Consumption of more than 9 alcoholic drinks per week or more than 4 drinks per occasion
- Regular probiotic or prebiotic use in the last month
- Any condition or medication that might interfere with study results, as decided by the investigator
AI-Screening
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Trial Site Locations
Total: 1 location
1
Örebro University
Örebro, Sweden
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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