Actively Recruiting
Effects of Propofol on Brain Function in Patients With Parkinson's Disease
Led by Beijing Tiantan Hospital · Updated on 2023-06-27
600
Participants Needed
1
Research Sites
173 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Propofol is a short-acting general anesthetic drug commonly used in clinical practice, with rapid clinical onset of action, amnesic, anxiolytic, antiepileptic, and muscle relaxant effects. The lack of natural antioxidants in patients with Parkinson's disease and propofol's ability to protect the brain by inhibiting oxidative stress, its pharmacokinetic and pharmacodynamic properties make propofol a suitable anesthetic drug for functional stereotactic surgery in patients with Parkinson's disease. However, changes in brain functional status during propofol anesthesia in Parkinson's patients are unknown. There is a lack of data from extensive clinical studies to support the need for propofol dosing during induction of anesthesia compared with non-Parkinson patients. This study is a prospective cohort study designed to compare the differences in propofol dosing requirements during induction of propofol anesthesia in patients with PD versus non-PD and to monitor the characteristics of altered brain functional status such as EEG and cerebral blood flow autoregulation capacity in PD versus non-PD patients during the perioperative period.
CONDITIONS
Official Title
Effects of Propofol on Brain Function in Patients With Parkinson's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 80 years
- ASA class I to III
- For PD group: primary or hereditary Parkinson's disease, responding well to compounded levodopa, scheduled for bilateral deep brain stimulation surgery
- For non-PD group: no previous diagnosed neurological disease or dysfunction, scheduled for non-neurosurgical, non-cardiac surgery
- Informed consent obtained
You will not qualify if you...
- Obstructive sleep apnea
- Body mass index (BMI) over 30 kg/m2
- Estimated difficult airway
- Allergy to anesthetic drugs
- Serious dysfunction of important organs such as heart, kidney, or liver
- History of craniocerebral trauma or surgery causing skull or brain defects
- Alcohol or drug addiction
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Beijing Tiantan Hospital, Capital Medical University
Beijing, Beijing Municipality, China
Actively Recruiting
Research Team
R
Ruquan Han, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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