Study of Propofol Anesthesia Effects on Brain Function During Surgery in Adults With Parkinsons Disease Compared to Non-Parkinsons Patients

What this Trial Is About

Researchers are studying how the anesthetic drug propofol affects brain function in patients with Parkinsons disease PD compared to patients without PD. Propofol is commonly used during surgery because it acts quickly and has properties that may protect the brain by reducing oxidative stress. This observational study aims to compare the amount of propofol needed to induce anesthesia and monitor changes in brain activity and blood flow regulation during surgery between PD and non-PD patients. Participants receive propofol using a target-controlled infusion pump with a starting dose adjusted until unconsciousness is reached. Propofol levels and brain function are closely monitored before, during, and after anesthesia induction, including at intubation and skin incision times. The study includes two groups patients with Parkinsons disease undergoing bilateral deep brain stimulation surgery and non-Parkinson patients undergoing other non-neurosurgical, non-cardiac surgeries. During the study, participants will have their brain electrical activity EEG and cerebral blood flow autoregulation measured at various times up to three days after surgery. Researchers will also assess patient satisfaction with sedation. The main outcome is the dose of propofol used during the trial, with secondary outcomes focused on brain signal features and blood flow control. The study lasts up to three days for each participant, with multiple assessments conducted throughout this period.

Effects of Propofol on Brain Function in Patients With Parkinson's Disease