Daily Plant or Animal Protein Supplements to Improve Brain Function in Overweight or Obese Older Adults Aged 60 to 75

What this Trial Is About

Researchers are investigating how daily protein supplementation affects brain function in overweight or obese older adults aged 60 to 75. The study focuses on comparing the effects of plant-derived and animal-derived proteins on brain insulin-sensitivity and vascular function. The goal is to see if these protein supplements can enhance cognitive performance and help regulate appetite, using advanced brain imaging techniques to measure these effects. Participants will consume protein supplements twice daily for two weeks in a randomized order. The supplements include a plant-based protein isolate fava bean, an animal-based protein isolate milk, and a control supplement made of cornstarch without extra protein. Each participant will receive all three interventions in separate periods to compare their effects. During the study, researchers will assess cerebral blood flow responses before and after administering intranasal insulin spray to measure brain vascular function and insulin-sensitivity using MRI. They will also evaluate cognitive performance and brain activity related to appetite. The total involvement includes baseline screening, two-week supplementation periods, and brain scans to track changes, with careful monitoring to ensure safety and adherence to the protocol.

Effects of Protein Supplementation on Brain Function