Actively Recruiting
Effects of Relighting on Smoke Toxicant Deliveries and Subjective Smoking Measures
Led by Masonic Cancer Center, University of Minnesota · Updated on 2026-02-04
30
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
Sponsors
M
Masonic Cancer Center, University of Minnesota
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying how relighting cigarettes affects the amount of harmful smoke toxicants delivered and smokers' subjective experiences. This study involves 30 adult smokers who regularly relight their cigarettes. The goal is to compare smoking intensity and toxicant levels between relit cigarettes and those smoked continuously without relighting, using both natural environment assessments and controlled in-clinic measurements. Participants will smoke their own usual brand cigarettes under two conditions: continuous smoking and relit smoking. During clinic visits, participants are randomly assigned to start with one condition and then switch to the other after 60 minutes. Visits are spaced 7 to 10 days apart to allow collection of cigarette butts over different days including weekdays and weekends. Throughout the study, researchers will measure smoking patterns, collect cigarette butts, and assess subjective responses before and after smoking sessions. They will analyze nicotine levels and puff volumes over one month to understand the impact of relighting. Participants' health and smoking behaviors will be monitored, and the total study duration spans from the initial visit through follow-up assessments.
CONDITIONS
Brief Title
Effects of Relighting on Smoke Toxicant Deliveries and Subjective Smoking Measures
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Smoking at least 10 cigarettes per day for at least 1 year confirmed by CO > 8 ppm or NicAlert test of 6
- Engaging in relighting for at least half of daily cigarettes smoked
- No quit attempts in the past month and no plans to quit in the next month
- Stable medical or psychiatric condition with systolic blood pressure < 160, diastolic blood pressure < 100, and heart rate < 105 bpm
- Adults aged 21 years or older
You will not qualify if you...
- Current or recent alcohol or drug abuse problems (other than marijuana) within the past month
- Trying or planning to quit smoking in the next month
- Planning to become pregnant, currently pregnant, or breastfeeding (pregnancy confirmed by urine test)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Approximately 2 weeks
Participants attend two study visits separated by 7 to 10 days. During each visit, participants smoke their own usual brand cigarettes under two conditions: continuous smoking and relight smoking. Each condition lasts about 60 minutes, with a crossover to the alternate condition within the same visit. Measures are taken before and after smoking in each condition, and cigarette butts are collected.
2 visits (in-person) separated by 7 to 10 days
Trial Site Locations
Total: 1 location
1
Irina Stepanov, PhD
Minneapolis, Minnesota, United States, 55455
Actively Recruiting
Research Team
I
Irina Stepanov, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
OTHER
Number of Arms
2
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