Actively Recruiting
Effects of Repetitive Transcranial Magnetic Stimulation in Patients With Alzheimer's Disease
Led by First Affiliated Hospital of Zhejiang University · Updated on 2025-05-11
30
Participants Needed
1
Research Sites
93 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Previous studies have shown that repetitive transcranial magnetic stimulation (rTMS) can improve cognitive function in Alzheimer's disease (AD), but studies on the improvement of sleep disorders in AD are limited. The aim of this study was to evaluate the effects of rTMS on sleep and cognition in patients with mild-to-moderate Alzheimer's disease (AD).
CONDITIONS
Official Title
Effects of Repetitive Transcranial Magnetic Stimulation in Patients With Alzheimer's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participant meets 2014 IWG-2 criteria for hippocampal amnestic syndrome typical of Alzheimer's disease with progressive episodic memory impairment confirmed by neuropsychology
- Cerebrospinal fluid markers or AV-45 PET imaging consistent with Alzheimer's disease pathophysiology
- Aged between 55 and 80 years
- No visual or hearing impairment
- Right-handed
- Han nationality
- Signed informed consent
- Has reliable caregivers to provide information
- MMSE score between 10 and 27; Clinical Dementia Rating (CDR) between 0.5 and 2 points
- If on approved Alzheimer's disease treatment, dose must be stable for at least 3 months prior and unchanged unless medically necessary
You will not qualify if you...
- History of seizures or epilepsy diagnosis
- History of stroke
- Nervous system diseases causing brain dysfunction such as schizophrenia, severe anxiety or depression, dementia other than Alzheimer's, Huntington's disease, brain tumors, Parkinson's disease, metabolic encephalopathy, encephalitis, multiple sclerosis, epilepsy, brain trauma, or hydrocephalus
- Severe liver, kidney, or lung dysfunction; anemia; gastrointestinal diseases; arrhythmia; recent myocardial infarction
- Use of barbiturates or benzodiazepines within 2 weeks
- Contraindications to MRI or TMS such as metallic implants
- Systemic diseases causing cognitive impairment including hypothyroidism, folate or vitamin B12 deficiency, infections, alcohol or drug abuse
- Aphasia, consciousness disturbances, or inability to cooperate
- Previous treatment with TMS, transcranial direct current stimulation, or deep brain stimulation
- Underlying pathology other than Alzheimer's disease
- Focal brain lesions on MRI T1/T2 images
- Refusal to sign informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The First Affiliated Hospital of Zhejiang University
Hangzhou, Zhejiang, China, 310003
Actively Recruiting
Research Team
G
Guoping Peng, Doctor
CONTACT
X
Xiaoyan Liu, Doctor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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