Actively Recruiting
Effects of a Resistance Exercise Training Program on Skeletal Muscle Quality, Functional Capacity, and Quality of Life in Young Individuals With and Without Hereditary Sensorimotor Polyneuropathy
Led by Universidad de La Frontera · Updated on 2025-09-23
22
Participants Needed
2
Research Sites
8 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the effects of an 8-week resistance exercise training program on muscle quality, functional capacity, and quality of life in young people aged 15 to 29 years, both with and without Hereditary Sensorimotor Polyneuropathy (HSPN), also known as Charcot-Marie-Tooth disease. This condition causes muscle weakness, atrophy, sensory loss, and balance problems, which reduce muscle quality and daily function. The trial aims to compare improvements in these areas after the exercise program, especially to see if those with HSPN show greater gains due to their initial impairments. Participants will take part in a supervised lower-limb progressive resistance exercise program three times a week for eight weeks. The program involves exercises like leg press, knee extension, knee flexion, and ankle dorsiflexion with increasing loads from 60% to 80% of their one-repetition maximum strength. Both groups—those with HSPN and healthy controls—will undergo the same exercise routine and have assessments before and after the intervention to evaluate changes. During the study, participants will complete evaluations including ultrasound scans of muscle structure, tests of muscle strength and functional capacity, body composition measurements, and quality of life questionnaires. Blood samples will be taken to check muscle regeneration markers. Researchers will monitor adherence and assess outcomes such as balance, gait, aerobic capacity, and handgrip strength. The study lasts for the 8-week program plus pre- and post-assessments conducted within days of starting and finishing the exercises.
CONDITIONS
Brief Title
Effects of Resistance Exercises in Hereditary Sensory-Motor Neuropathy (Charcot-Marie-Tooth Disease)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Men or women between 15 and 29 years of age with a diagnosis of hereditary sensorimotor polyneuropathy (HSPN) in any subtype, living in the community (experimental group).
- Healthy men or women between 15 and 29 years of age living in the community (control group).
- Active ankle movement from plantarflexion to at least 0 degrees dorsiflexion to allow strength training.
You will not qualify if you...
- Osteoarticular or mobility impairments preventing safe performance of resistance exercise training (e.g., ankle arthrodesis).
- Use of nutritional supplements affecting skeletal muscle regulation (such as leucine, glutamine, casein, whey protein, fatty acids, creatine).
- Untreated or uncontrolled chronic diseases or intellectual disability.
- History of surgery.
- Participation in a resistance exercise training program within the past 6 months.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 8 weeks
Participants undergo an 8-week supervised progressive resistance exercise training program focused on lower limbs, performed 3 times per week. This program includes exercises such as leg press, knee extension, knee flexion, and ankle dorsiflexion with load progression from 60% to 80% of one-repetition maximum.
3 visits per week for 8 weeks
Duration - Up to 1 week after treatment
Participants complete post-intervention assessments to evaluate changes in muscle quality, functional capacity, and quality of life after the 8-week training program.
1 visit (in-person) shortly after completing treatment
Trial Site Locations
Total: 2 locations
1
Temuco, Chile
Temuco, La Araucanía, Chile, 4812790
Actively Recruiting
2
Universidad de La Frontera
Temuco, La Araucanía, Chile, 4812790
Active, Not Recruiting
Research Team
F
Fernando J Valenzuela, MSc
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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