Actively Recruiting
Effects of Resistance Exercises in Hereditary Sensory-Motor Neuropathy (Charcot-Marie-Tooth Disease)
Led by Universidad de La Frontera · Updated on 2025-09-23
22
Participants Needed
2
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to compare the effects of an 8-week resistance exercise training program on skeletal muscle quality, functional capacity, and quality of life in young individuals aged 15 to 29 years, with and without Hereditary Sensorimotor Polyneuropathy (HSPN). The main questions to answer are: What is the effect of an 8-week resistance exercise training program on skeletal muscle quality, functional capacity, and quality of life in young individuals with and without HSPN? Will the percentage of improvement after the program be greater in participants with HSPN compared to those without, due to greater baseline alterations? Researchers will compare the resistance exercise training program with baseline conditions to determine its effectiveness in improving skeletal muscle quality, functional capacity, and quality of life. Participants will undergo a supervised lower-limb resistance exercise program (3x/week) for 8 weeks. The intervention will include progressive loads from 60% to 80% of 1-Repetition Maximum (1RM), with exercises targeting the major lower limb muscle groups. All participants will complete pre- and post-intervention evaluations, including ultrasound assessment of muscle architecture, functional capacity tests, strength measurements, body composition analysis, and quality of life questionnaires.
CONDITIONS
Official Title
Effects of Resistance Exercises in Hereditary Sensory-Motor Neuropathy (Charcot-Marie-Tooth Disease)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Men or women between 15 and 29 years of age with a diagnosis of hereditary sensorimotor polyneuropathy (HSPN) in any subtype, living in the community (experimental group).
- Healthy men or women between 15 and 29 years of age living in the community (control group).
- Ability to actively move ankle from plantarflexion to at least 0 degrees dorsiflexion, allowing strength training.
You will not qualify if you...
- Osteoarticular or mobility impairments preventing safe resistance exercise training (e.g., ankle arthrodesis).
- Use of nutritional supplements affecting skeletal muscle regulation (leucine, glutamine, casein, whey protein, fatty acids, creatine, etc.).
- Untreated or uncontrolled chronic diseases or intellectual disability.
- History of surgery.
- Participation in resistance exercise training within the past 6 months.
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Temuco, Chile
Temuco, La Araucanía, Chile, 4812790
Actively Recruiting
2
Universidad de La Frontera
Temuco, La Araucanía, Chile, 4812790
Active, Not Recruiting
Research Team
F
Fernando J Valenzuela, MSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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