Actively Recruiting

Phase Not Applicable
Age: 50Years - 65Years
FEMALE
ID06538454

Acute and Chronic Effects of Resistance Training Intensity on Cardiovascular Parameters of Postmenopausal Women With Systemic Arterial Hypertension

Led by University of Sao Paulo · Updated on 2024-08-05

24

Participants Needed

1

Research Sites

52 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are studying how different intensities of resistance training (RT) affect cardiovascular health in postmenopausal women with systemic arterial hypertension (SAH). They aim to find out if training at 60% or 80% of one repetition maximum (1RM) influences blood pressure, heart rate and its variability, endothelial function, nitric oxide levels, mood, and perceived effort. The study includes both an acute experiment and a chronic experiment to assess these effects over time. In the acute experiment, participants perform two RT sessions in random order, one at 60% 1RM and another at 80% 1RM. Blood pressure, heart rate, and heart rate variability are measured before, immediately after, and for one hour post-exercise. Mood and perceived exertion are also recorded. In the chronic experiment, participants are randomly assigned to train at either 60% or 80% 1RM for 10 weeks, with two sessions per week. Assessments occur before, during, and after this period, including measures of endothelial function, heart rate variability, and salivary nitric oxide. Participants will attend multiple sessions over about 10 weeks and undergo evaluations involving blood pressure, heart rate, mood, perceived exertion, endothelial function, and nitric oxide levels. The study tracks blood pressure changes up to one year and uses questionnaires and physiological tests to monitor cardiovascular responses. The research evaluates both immediate and long-term effects of RT intensity on cardiovascular health and related factors in this specific group of women.

CONDITIONS

Brief Title

Effects of Resistance Training Intensity on Cardiovascular Parameters of Hypertensive Women

Who Can Participate

Age: 50Years - 65Years
FEMALE

Eligibility Criteria

Eligible

You may qualify if you...

  • Women aged 50 to 65 years
  • Postmenopausal diagnosis (no menstrual periods for 12 months or more)
  • Previous diagnosis of hypertension treated with medications
  • Physically inactive
Not Eligible

You will not qualify if you...

  • History of cardiovascular problems such as heart failure, heart attack, or stroke
  • Grade II obesity with BMI 35 kg/m² or higher
  • Use of beta-blockers or non-dihydropyridine calcium channel blockers
  • Resting systolic blood pressure above 160 mmHg or diastolic above 105 mmHg
  • Unable to perform resistance exercise due to musculoskeletal or cognitive issues

AI-Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Acute Resistance Training Sessions

Duration - Short-term, within a few days

Participants perform two separate resistance training sessions at different intensities (60% and 80% of 1 repetition maximum) in a crossover design. Blood pressure, heart rate, heart rate variability, affectivity, and perceived exertion are measured before, immediately after, and for one hour post-exercise.

2 visits (in-person)

Chronic Resistance Training

Duration - 10 weeks

Participants are randomized into groups training at either 60% or 80% of 1 repetition maximum intensity for 10 weeks with 2 weekly sessions. Evaluations of blood pressure, heart rate, affective responses, and perceived exertion occur before, during, and after the intervention. Endothelial function, heart rate variability, and salivary nitric oxide levels are measured before and after the intervention.

Approximately 20 sessions (in-person) plus baseline and post-intervention assessments

Trial Site Locations

Total: 1 location

1

Laboratório de Fisiologia do Exercício e Metabolismo

Ribeirão Preto, São Paulo, Brazil

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Research Team

L

Leonardo S Gonçalves

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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