Actively Recruiting
Effects of Resistance Training on Sarcopenia in Older Patients With Chronic Heart Failure: A Randomized Controlled Trial
Led by Kieu Nguyen Dang Phuong · Updated on 2026-04-30
146
Participants Needed
2
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to evaluate the effects of an eight-week machine-based resistance training program on sarcopenia in older outpatients with chronic heart failure. The study involves older adults diagnosed with both conditions and seeks to understand how resistance training might impact muscle strength and physical performance compared to usual care. Participants will be randomly assigned to either the resistance training group or the usual care group. Participants in the resistance training group will receive heart failure treatment as prescribed by their cardiologists and continue their usual medications and lifestyle habits. They will train three nonconsecutive days per week for eight weeks using specialized machines including the Proxomed Compass 540 and HUR devices, performing exercises like leg press, calf raise, leg curl, chest press, push up, and seated row. The training intensity will range from 30% to 60% of their one-repetition maximum, with three sets of 8 to 12 repetitions per exercise. The usual care group will continue their prescribed heart failure treatment and maintain their regular physical activity and diet. During the study, participants will be assessed at baseline and after eight weeks for changes in muscle strength, measured by handgrip strength, gait speed, and performance on the five-times sit-to-stand test. Researchers will monitor participants weekly by phone to ensure adherence and safety. The total study period is eight weeks, focusing on evaluating muscle strength improvements and physical function related to sarcopenia in this population.
CONDITIONS
Brief Title
Effects of Resistance Training on Sarcopenia in Older Patients With Chronic Heart Failure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 60 years or older
- Diagnosed with sarcopenia according to 2019 AWGS2 criteria based on muscle mass, handgrip strength, or walking speed
- Diagnosed with chronic heart failure following ESC 2021 criteria
- Able to understand the study purpose and provide informed consent
You will not qualify if you...
- Early stage after acute coronary syndrome (within 2 days)
- Unstable coronary artery disease
- Decompensated heart failure
- Acute venous thrombosis or recent arterial embolism
- Acute myocarditis, pericarditis, or endocarditis
- Aortic dissection or valve disease
- Severe symptomatic aortic stenosis
- Acute systemic illness or fever
- Uncontrolled or life-threatening arrhythmias
- Uncontrolled tachycardia (resting heart rate > 120 bpm)
- Third-degree AV block
- Uncontrolled diabetes
- Symptomatic orthostatic hypotension (> 20 mmHg)
- Recent increasing fatigue or shortness of breath in past 3-5 days
- Significant myocardial ischemia at low workloads
- Weight gain ≥ 1.8 kg in past 1-3 days
- Use of continuous or intermittent Dobutamine
- Blood pressure decrease with exercise
- NYHA class IV heart failure
- Complex ventricular arrhythmias at rest or with exertion
- Resting heart rate ≥ 100 bpm when lying down
- Comorbidities limiting exercise
- Severe obstructive hypertrophic cardiomyopathy
- Participation in cardiovascular rehabilitation program within last 6 months
- Declines to participate in the study
AI-Screening
AI-Powered Screening
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Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 8 weeks
Participants are assigned to either machine-based resistance training or usual care. Those in the resistance training group train 3 non-consecutive days per week for 8 weeks under professional supervision, while those in the usual care group continue their standard heart failure treatment and usual activities.
3 training days per week for 8 weeks; weekly phone contacts for usual care group
Trial Site Locations
Total: 2 locations
1
Military Hospital 175
Ho Chi Minh City, Vietnam, 700000
Actively Recruiting
2
University of Medicine and Pharmacy at Ho Chi Minh City
Ho Chi Minh City, Vietnam, 700000
Actively Recruiting
Research Team
N
Nguyen Dang P Kieu, M.D.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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