Actively Recruiting
Effects of Sedation, TEmperature and Pressure After Cardiac Arrest and REsuscitation on Major Adverse Kidney Events (STEPCARE-MAKE)
Led by Helsinki University Central Hospital · Updated on 2026-05-14
3500
Participants Needed
52
Research Sites
171 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The STEPCARE-MAKE study is a predefined sub-study of the large Sedation, TEmperature and Pressure after Cardiac Arrest and REsuscitation (STEPCARE) trial, which evaluates the effects of three interventions in comatose adult patients resuscitated from out-of-hospital cardiac arrest. In this sub-study, all 3500 participants enrolled in the main trial are assessed for major adverse kidney events (MAKE) and creatinine kinetics.
CONDITIONS
Official Title
Effects of Sedation, TEmperature and Pressure After Cardiac Arrest and REsuscitation on Major Adverse Kidney Events (STEPCARE-MAKE)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- All patients included in the main STEPCARE trial are also included in this sub-study
- Out-of-hospital cardiac arrest
- Sustained return of spontaneous circulation for at least 20 minutes without chest compressions
- Unconsciousness defined as FOUR-score motor response less than 4, inability to obey verbal commands, or intubated and sedated due to agitation
- Eligible for intensive care without restrictions or limitations
- Inclusion within 4 hours of return of spontaneous circulation
You will not qualify if you...
- Out-of-hospital cardiac arrest of presumed traumatic or hemorrhagic origin
- Confirmed or suspected intracranial hemorrhage
- Pregnancy
- Extracorporeal membrane oxygenation (ECMO) prior to randomization
- No additional exclusion criteria beyond those of the main STEPCARE trial
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 52 locations
1
Princess Alexandra Hospital
Brisbane, Australia
Actively Recruiting
2
The Prince Charles Hospital
Brisbane, Australia
Actively Recruiting
3
Nepean Hospital
Kingswood, Australia
Actively Recruiting
4
Liverpool Hospital
Liverpool, Australia
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5
Austin Hospital
Melbourne, Australia
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6
Royal North Shore Hospital
Sydney, Australia
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7
St George Hospital
Sydney, Australia
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8
The Sutherland Hospital
Sydney, Australia
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9
HUB Hôpital Erasme
Brussels, Belgium
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10
Ghent University Hospital
Ghent, Belgium
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11
Ziekenhuis Oost-Limburg Hospital
Lanaken, Belgium
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12
North Estonia Medical Centre
Tallinn, Estonia
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13
Jorvi Hospital
Espoo, Finland
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14
Meilahti Hospital
Helsinki, Finland, 00290
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15
Jyväskylä Hospital
Jyväskylä, Finland
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16
Kuopio University Hospital
Kuopio, Finland
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17
Oulu University Hospital
Oulu, Finland
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18
Charite University Hospital
Berlin, Germany
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19
Lübeck University Hospital
Lübeck, Germany
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20
Tubingen University Hospital
Tübingen, Germany
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21
San Martino Hospital Genova
Genova, Italy
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22
Centre Hospitalier de Luxembourg
Luxembourg, Luxembourg
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23
DCCM ICU
Auckland, New Zealand
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24
Middlemore ICU
Auckland, New Zealand
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25
North Shore ICU NZ
Auckland, New Zealand
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26
Christchurch Hospital
Christchurch, New Zealand
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27
Wellington Hospital
Wellington, New Zealand
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28
Soerlandet Hospital Arendal
Arendal, Norway
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29
Kalnes Hospital
Grålum, Norway
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30
Oslo University Hospital
Oslo, Norway
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31
Stavanger University Hospital
Stavanger, Norway
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32
King Abdulaziz Medical City
Riyadh, Saudi Arabia
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33
Tan Tock Seng Hospital
Singapore, Singapore
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34
Sahlgrenska University Hospital
Gothenburg, Sweden
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35
Hallands hospital
Halmstad, Sweden
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36
Helsingborg Hospital
Helsingborg, Sweden
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37
Karlstad hospital
Karlstad, Sweden
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38
Skåne University Hospital
Lund, Sweden
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39
Skåne University Hospital Malmö
Malmö, Sweden
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40
Skaraborg Hospital Skovde
Skövde, Sweden
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41
Karolinska University Hospital
Stockholm, Sweden
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42
University Hospital of Umeå
Umeå, Sweden
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43
Bern University Hospital
Bern, Switzerland
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44
St Gallen Hospital
Sankt Gallen, Switzerland
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45
University Hospital Zürich
Zurich, Switzerland
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46
Essex Cardiothoracic Centre
Basildon, United Kingdom
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47
Bristol Royal Infirmary
Bristol, United Kingdom
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48
Cardiff University Hospital
Cardiff, United Kingdom
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49
Leeds General Infirmary
Leeds, United Kingdom
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50
Kings College Hospita
London, United Kingdom
Actively Recruiting
51
St Bartholomew's Hospital
London, United Kingdom
Actively Recruiting
52
St Georges University Hospital
London, United Kingdom
Actively Recruiting
Research Team
M
Markus B Skrifvars, Prof
CONTACT
M
Miikka Keski-Keturi, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
FACTORIAL
Primary Purpose
TREATMENT
Number of Arms
8
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