Randomized Trial Comparing Short and Long Intermittent Hypoxic-Hyperoxic Training in Adults Aged 50-74 With Type 2 Diabetes

What this Trial Is About

Researchers are evaluating the effectiveness and safety of short versus long courses of intermittent hypoxic-hyperoxic training IHHT in patients aged 50 to 74 years with type 2 diabetes. This single-center randomized controlled trial compares a 3-day IHHT course, a 10-day IHHT course, and a control group receiving a constant oxygen gas mixture. The primary focus is on changes in fasting glucose and HbA1c levels, with secondary measures including cardiovascular health, quality of life, cognitive function, and biological age. Participants are randomly assigned to one of three groups the short course group receives three daily IHHT sessions lasting 24 minutes each with cycles of low and high oxygen levels the long course group receives ten daily IHHT sessions lasting 40 minutes each excluding weekends and holidays the control group receives ten daily sessions breathing a gas mixture with constant oxygen at 21% for 40 minutes excluding weekends and holidays. The IHHT sessions use the HYPO-OXY-1 OXYTERRA device targeting oxygen saturation levels between 80-85%. During the study, participants undergo assessments at baseline, during the intervention, and about 30 days after completing the sessions. These include blood tests for fasting glucose and HbA1c, cardiovascular measurements like the Cardio-Ankle Vascular Index and blood pressure monitoring, quality of life and cognitive function questionnaires, anxiety and depression scales, biological age evaluation, and a 6-minute walk test. Safety and adherence are monitored throughout the intervention and follow-up periods, with the total participation lasting over one month post-intervention.

Effects of Short and Long Courses of Intermittent Hypoxic-Hyperoxic Training in Patients With Type 2 Diabetes Including Elderly