Actively Recruiting
Effects of Short and Long Courses of Intermittent Hypoxic-Hyperoxic Training in Patients With Type 2 Diabetes Including Elderly
Led by National Medical Research Center for Therapy and Preventive Medicine · Updated on 2026-05-07
250
Participants Needed
1
Research Sites
113 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a single-center randomized controlled trial evaluating the efficacy and safety of short (3 days) versus long (10 days) courses of intermittent hypoxic-hyperoxic training (IHHT) in patients with type 2 diabetes mellitus aged 50-74 years. Participants will be randomized into three groups: 3-day IHHT course (n≥100), 10-day IHHT course (n≥100), or control group receiving gas mixture with constant O2 21% for 10 days (n≥50). The primary outcomes are fasting glucose levels and HbA1c. Secondary outcomes include cardiovascular parameters, quality of life, cognitive function, and biological age.
CONDITIONS
Official Title
Effects of Short and Long Courses of Intermittent Hypoxic-Hyperoxic Training in Patients With Type 2 Diabetes Including Elderly
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 50-74 years inclusive
- Confirmed diagnosis of type 2 diabetes mellitus
- Stable diabetes and chronic disease therapy for at least 4 weeks before enrollment
- Ability to follow study protocol requirements
- Signed informed consent
You will not qualify if you...
- Type 1 diabetes mellitus
- Acute diabetes complications within past 6 months (diabetic ketoacidosis, hyperosmolar state, lactic acidosis, hypoglycemic coma)
- Acute or active chronic infections
- Angina pectoris functional class III-IV
- Uncontrolled grade 3 arterial hypertension (SBP 65180 and/or DBP 65110 mmHg)
- Recent acute cerebrovascular accident, myocardial infarction, surgery, or significant injuries within 6 months
- Internal carotid artery stenosis greater than 60% or symptomatic stenosis 50-99%
- Chronic obstructive pulmonary disease or bronchial asthma
- Exacerbation or decompensation of chronic diseases within 1 month
- Elevated ALT and/or AST levels more than 2-3 times upper limit of normal
- Congenital heart or major vessel abnormalities
- Implanted cardiac pacemaker
- Cancer remission less than 5 years
- Mental illness, drug addiction, or alcohol dependence
- Pregnancy
- Inability to participate throughout the study period
AI-Screening
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Trial Site Locations
Total: 1 location
1
National Medical Research Center for Therapy and Preventive Medicine
Moscow, Russia
Actively Recruiting
Research Team
M
Mikhail G Chashchin, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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