Actively Recruiting
The Effects of Sirolimus in Patients With Dilated Cardiomyopathy Infected With Kaposi Sarcoma-associated Virus
Led by Tongji Hospital · Updated on 2024-02-01
276
Participants Needed
1
Research Sites
260 weeks
Total Duration
On this page
Sponsors
T
Tongji Hospital
Lead Sponsor
W
Wuhan Central Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Evaluating the efficacy of sirolimus (compared to standard therapy alone) in the treatment of dilated cardiomyopathy infected with Kaposi Sarcoma-associated virus -- a multicenter randomized controlled study.
CONDITIONS
Official Title
The Effects of Sirolimus in Patients With Dilated Cardiomyopathy Infected With Kaposi Sarcoma-associated Virus
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 to 70 years of age
- Diagnosed with dilated cardiomyopathy confirmed by (i) left ventricular ejection fraction <45% or fractional shortening <25%, (ii) left ventricular end-diastolic diameter >117% of predicted value adjusted for age and body surface area, and (iii) absence of severe coronary artery or valvular disease
- Positive for KSHV DNA seropositivity
- Voluntary participation with signed informed consent
You will not qualify if you...
- Allergy to rapamycin or its derivatives
- Neutrophil count less than 0.510^9/L or platelet count less than 2.510^10/L
- Pregnant women or planning pregnancy
- Participation in any drug clinical trials within the last 3 months
- Serious neurological diseases including Alzheimer's disease, Parkinson syndrome, progressive lower limb disorders, or deafness
- Previous cancer or tumor history, or confirmed precancerous lesions
- Patients not optimally managed
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Tongji Hospital
Wuhan, Hubei, China, 430030
Actively Recruiting
Research Team
Y
Yanru Zhao, Doctor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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